|5,7-二羟基-6-甲氧基-2-苯基-4H-苯并吡喃-4-酮|CsnPharm

CAS No.: 480-11-5

千层纸素A Catalog No. CSN11617

Synonyms: Baicalein 6-methyl ether;6-Methoxybaicalein;千层纸素A

Oroxylin A shows inhibition of the dopamine reuptake and allosteric modulation of GABAA receptor. It is a natural active flavonoid isolated from scutellaria baicalensis and oroxylum indicum.

规格	价格	促销价格	库存	数量

400-920-2911

sales@csnpharm.cn

tech@csnpharm.cn

加入购物车大规格询价

加入收藏

产品咨询

400-920-2911

sales@csnpharm.cn

tech@csnpharm.cn

纯度 & 质量文件批次:

靶点选择性

生物活性

实验方案

技术信息

生物活性

描述Oroxylin A is a natural active flavonoid with strong anticancer effects both in vitro and in vivo. Oroxylin A did not directly affect the transcription of wt-p53, but suppressed the MDM2-mediated degradation of p53 via downregulating MDM2 (mouse double minute 2) transcription in wt-p53 cancer cells. In vivo, oroxylin A inhibited the tumor growth of nude mice-inoculated MCF-7 or HCT116 cells. The expression of MDM2 protein in tumor tissue was downregulated by oroxylin A as well^[3]. Oroxylin A remarkably reduced the generation of lactate and glucose uptake under hypoxia in HepG2 cells. Moreover, oroxylin A inhibited HIF-1α expression and its stability. Furthermore, oroxylin A could reduce the expression of complex III in mitochondrial respiratory chain, and then decrease the accumulation of ROS at moderate concentrations (0 - 50 µM) under hypoxia, which was benefit for its inhibition on glycolytic activity by decreasing ROS-mediated HIF-1 expression^[4]. Oroxylin A promotes superoxide dismutase (SOD2) gene expression through SIRT3-regulated DNA-binding activity of FOXO3a and increases the activity of SOD2 by promoting SIRT3-mediated deacetylation. In vivo, oroxylin A inhibits the growth of transplanted human breast tumors associated with glycolytic suppression^[5].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 3.5179 mL
- 17.5893 mL
- 35.1786 mL
- 5 mM
- 0.7036 mL
- 3.5179 mL
- 7.0357 mL
- 10 mM
- 0.3518 mL
- 1.7589 mL
- 3.5179 mL

技术信息

CAS号

480-11-5

储存条件

粉末: Sealed in dry,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C16H12O5

运输

蓝冰

分子量

284.26

别名

Baicalein 6-methyl ether;6-Methoxybaicalein;千层纸素A

溶解度

DMSO	56.9 mg/mL (200.2 mM)

动物实验配方

大规格询价

号为必填项

姓名: 邮箱: 手机号:

留言:

提交

千层纸素A Catalog No. CSN11617

靶点选择性

请登录您的专属账户

确认信息