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CAS No.: 72-80-0

氯喹那多 Catalog No. CSN12911

Synonyms: Chloquinan;BRN-0156683;氯喹那多

Chlorquinaldol is a halogenated hydroxyquinoline mainly applied topically in infected skin conditions and in vaginal infections.

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400-920-2911

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实验方案

技术信息

生物活性

描述Chlorquinaldol, is a derivative of 8-hydroxyquinoline which is usually administered topically for the treatment of skin infections, alone or in combination with diflucortolone valerate. in vitro，staphylococci was most sensitive to chlorquinaldol, with MIC-values ranging from 0.016 to 0.5 mg/L. A lower activity was observed against Gram-negative bacteria, with 77% of the isolates being inhibited at concentrations ranging from 128 to 512 mg/L^[3]. in vitro, for 0.1 to 0.2% (W/V) chlorquinaldol concentrations, a reduction of about 10 (4) organisms was obtained after 60 minutes for N. gonorrhoeae and C. trachomatis^[4].
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT01153958	Vaginosis, Bacterial	Phase 4	Terminated	-	China ... more >> Peking University People's Hospital Beijing, China Second Hospital of West China Medical School, Sichuan University Chengdu, China Obstetrics & Gynaecology Hospital of Fudan University Shanghai, China Peking University Shenzhen Hospital Shenzhen, China Wuhan Union Hospital of China Wuhan, China Collapse <<
NCT01153958	-	-	Terminated	-	-

参考文献

[1] Corrihons I, Dutilh B, et al. [In vitro activity of an antiseptic, chlorquinaldol, against Neisseria gonorrhoeae and Chlamydia trachomatis] . Pathol Biol (Paris). 1991 Feb;39(2):136-9.
[2] Mett H, Gyr K, et al. Duodeno-pancreatic secretions enhance bactericidal activity of antimicrobial drugs. Antimicrob Agents Chemother. 1984 Jul;26(1):35-8.
[3] Bortolin M, Bidossi A, De Vecchi E, Avveniente M, Drago L. In vitro Antimicrobial Activity of Chlorquinaldol against Microorganisms Responsible for Skin and Soft Tissue Infections: Comparative Evaluation with Gentamicin and Fusidic Acid. Front Microbiol. 2017;8:1039. Published 2017 Jun 8.
[4] Corrihons I, Dutilh B, Bébéar C. Activité in vitro d'un antiseptique, le chlorquinaldol, sur Neisseria gonorrhoeae et Chlamydia trachomatis [In vitro activity of an antiseptic, chlorquinaldol, against Neisseria gonorrhoeae and Chlamydia trachomatis]. Pathol Biol (Paris). 1991;39(2):136-139.

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 4.3845 mL
- 21.9226 mL
- 43.8453 mL
- 5 mM
- 0.8769 mL
- 4.3845 mL
- 8.7691 mL
- 10 mM
- 0.4385 mL
- 2.1923 mL
- 4.3845 mL

技术信息

CAS号

72-80-0

储存条件

粉末: Keep in dark place,Sealed in dry,Room Temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C10H7Cl2NO

运输

蓝冰

分子量

228.07

别名

Chloquinan;BRN-0156683;氯喹那多

溶解度

DMSO	46.0 mg/mL (201.7 mM)
Water	Insoluble
Ethanol	6.0 mg/mL (26.3 mM)

动物实验配方

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