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CAS No.: 35354-74-6

和厚朴酚 Catalog No. CSN19405

Synonyms: 和厚朴酚;NSC 293100

Honokiol inhibits Akt activation and enhances ERK1/ERK2 phosphorylation, is a hydroxylated biphenyl compound isolated from the Chinese herb Magnolia officinalis with anticancer activities in a variety of cancer cell lines.

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靶点选择性

生物活性

实验方案

技术信息

生物活性

描述Honokiol is a phenylpropanoid molecule, a biaryl-type lignan, present in the genus Magnolia. Neonatal rats, when injected with honokiol (10 mg/kg), acute pain response was subdued. And the application of 25 mg/kg honokiol to guinea pig models lowered the testosterone level^[3]. In addition,honokiol was able to prevent doxorubicin (Dox)-induced senescence of H9c2 cardiomyocytes ^[4]. Honokiol (10 mg/kg, orally) effectively reversed the hepatotoxicity indices elevations and abnormal histopathological changes induced by Concanavalin A (Con A)^[5].
细胞研究

Cell Data

Cell Lines	Concentration	Assay Type	Time	Activity Description	Data Sources
HEK293 cells	-	Function assay	-	Agonist activity at RXRalpha in HEK293 cells assessed as transcriptional activation after 48 hrs by luciferase reporter gene assay, EC50=11.8 μM	20695472
HEK293 cells	-	Function assay	24-48 h	Agonist activity at human RXR-alpha expressed in HEK293 cells coexpressing with pCMX-beta-gal after 24 to 48 hrs by luciferase reporter gene assay	24959987
Hep-G2 cells	-	Cytotoxicity assay	-	Cytotoxicity of compound against human liver tumor cell line (Hep-G2) was determined, IC50=16.5 μM	15582432

更多
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT02310308	Dental Caries	Not Applicable	Unknown	November 2015	Italy ... more >> Department of Surgery, Microsurgery and Medicine Sciences University of Sassari Sassari, Sardinia, Italy, I-07100 WHO CC University of Milan Milan, Italy, I-20121 Collapse <<
NCT00966953	Gingival Diseases	Phase 3	Completed	-	United States, New York ... more >> Eastman Dental Center - University of Rochester Rochester, New York, United States, 14642-8315 Collapse <<
NCT00966953	-	-	Completed	-	-

参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 3.7547 mL
- 18.7734 mL
- 37.5468 mL
- 5 mM
- 0.7509 mL
- 3.7547 mL
- 7.5094 mL
- 10 mM
- 0.3755 mL
- 1.8773 mL
- 3.7547 mL

技术信息

CAS号

35354-74-6

储存条件

粉末: Sealed in dry,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C18H18O2

运输

蓝冰

分子量

266.33

别名

和厚朴酚;NSC 293100

溶解度

DMSO	53.0 mg/mL (199.0 mM)
Water	Insoluble
Ethanol	Insoluble

动物实验配方

2% DMSO+40% PEG 300+2% Tween 80+water

2 mg/mL

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Cell Lines	Concentration	Assay Type	Time	Activity Description	Data Sources

HEK293 cells	-	Function assay	-	Agonist activity at RXRalpha in HEK293 cells assessed as transcriptional activation after 48 hrs by luciferase reporter gene assay, EC50=11.8 μM	20695472
HEK293 cells	-	Function assay	24-48 h	Agonist activity at human RXR-alpha expressed in HEK293 cells coexpressing with pCMX-beta-gal after 24 to 48 hrs by luciferase reporter gene assay	24959987
Hep-G2 cells	-	Cytotoxicity assay	-	Cytotoxicity of compound against human liver tumor cell line (Hep-G2) was determined, IC50=16.5 μM	15582432
human A2780 cells	-	Proliferation assay	-	Antiproliferative activity against cisplatin-sensitive human A2780 cells by MTT assay, IC50=30.5 μM	19589678
human A549 cell	-	Cytotoxicity assay	24 h	Cytotoxicity against human A549 cells after 24 hrs by MTS assay, IC50=12.51 μM	22533983
human A549 cells	-	Cytotoxicity assay	-	Cytotoxicity against human A549 cells after 72 hrs by MTS assay, IC50=7.75 μM	22533983
human CEM cells	-	Cytotoxicity assay	-	Cytotoxicity against human CEM cells, IC50=10.9 μM	17587572
human HepG2 cells	-	Proliferation assay	24 h	Antiproliferative activity against human HepG2 cells after 24 hrs by MTT assay, IC50=16.5 μM	21853991
human HT-29 cells	-	Cytotoxicity assay	72 h	Cytotoxicity against human HT-29 cells after 72 hrs by MTS assay, IC50=13.24 μM	22533983
human K562 cells	-	Proliferation assay	-	Antiproliferative activity against human K562 cells by MTT assay, IC50=21.1 μM	19589678
human PBM cells	-	Cytotoxicity assay	-	Cytotoxicity against human PBM cells, IC50=16.1 μM	17587572
human SH-SY5Y cells	10 μM	Function assay	30 mins	Neuroprotective activity in human SH-SY5Y cells assessed as inhibition of CHP and TBHP-induced cell death at 10 uM incubated for 30 mins prior to challenge measured after 3 hrs by MTT assay	22142539
human SPC-A1 cells	-	Proliferation assay	-	Antiproliferative activity against human SPC-A1 cells by MTT assay, IC50=36.1 μM	19589678
human UACC-903 cells	-	Cytotoxicity assay	-	Cytotoxicity against human UACC-903 cells after 72 hrs by MTS assay, IC50=5.1 μM	22533983
human UACC-903 cells	-	Cytotoxicity assay	-	Cytotoxicity against human UACC-903 cells after 24 hrs by MTS assay, IC50=7.45 μM	22533983
HUVEC cells	20 μM	Function assay	24 h	Antimigratory activity against human HUVEC cells at 20 uM after 24 hrs by wound-healing assay	21853991
Vero cells	-	Cytotoxicity assay	-	Cytotoxicity against Vero cells, IC50=22.5 μM	16722664
Vero E6 cells	-	Function assay	-	Antiviral activity against SARS coronavirus in Vero E6 cells assessed as inhibition of viral replication by ELISA, EC50=6.5 μM	17663539

和厚朴酚 Catalog No. CSN19405

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