CAS No.: 315706-13-9
4EGI-1 Catalog No. CSN18206
Synonyms: eIF4E/eIF4G Interaction Inhibitor
4EGI-1 is an inhibitor of the cap-dependent translation initiation through disturbing the interaction between eIF4E and eIF4G, HNE1 cell line is the most sensitive one to 4EGI-1, and the IC50 of 4EGI-1 was about 50μM at 72h.
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纯度 & 质量文件
批次:
靶点选择性
生物活性
- 描述
- 参考文献
- [1] Fan S, Li Y, et al. The eIF4E/eIF4G interaction inhibitor 4EGI-1 augments TRAIL-mediated apoptosis through c-FLIP Down-regulation and DR5 induction independent of inhibition of cap-dependent protein translation. Neoplasia. 2010 Apr;12(4):346-56.
- [2] Moerke NJ, Aktas H, et al. Small-molecule inhibition of the interaction between the translation initiation factors eIF4E and eIF4G. Cell. 2007 Jan 26;128(2):257-67.
实验方案
- 计算器
- 储存液制备
技术信息
| CAS号 | 315706-13-9 | 储存条件 |
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| 分子式 | C18H12Cl2N4O4S | 运输 | 蓝冰 | |
| 分子量 | 451.28 | 别名 | eIF4E/eIF4G Interaction Inhibitor |
