|4-羟基嘧啶-2(1H)-硫酮|CsnPharm

CAS No.: 141-90-2

2-硫脲嘧啶 Catalog No. CSN12545

Synonyms: 2-硫脲嘧啶;Thiouracil;硫尿嘧啶

Thiouracil is a thyroid activity inhibitor fuctions by blocking thyroid peroxidase (TPO), was used as an anti-thyroid preparation.

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技术信息

生物活性

描述2-Thiouracil (Thiouracil) is an antithyroid compound. 2-Thiouracil is a selective inhibitor of neuronal nitric oxide synthase (nNOS) with a Ki of 20 μM. The drug apparently interfered with the substrate- and tetrahydrobiopterin (BH(4))-binding to the enzyme. It caused a 60% inhibition of H(2)O(2) production in the absence of L-arginine and BH(4), and antagonised BH(4)-induced dimerisation of nNOS, but did not affect cytochrome c reduction^[3]. 2-thiouridine (alone or within an RNA chain) is predominantly transformed under oxidative stress conditions to 4-pyrimidinone riboside (H2U) and not to uridine. 2-Thiouracil-containing nucleosides are essential modified units of natural and synthetic nucleic acids^[4]. 2-thiouracil could not inhibit the synthesis of TMV (tobacco mosaic virus) RNA, but could inhibit some early functions of TMV. 1 mM 2-thiouracil inhibited viral protein and RNA synthesis totally when treatment began within the first 4 h after initiation of replication, but not at all when treatment began at 12 h or later^[5].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 7.8034 mL
- 39.0168 mL
- 78.0336 mL
- 5 mM
- 1.5607 mL
- 7.8034 mL
- 15.6067 mL
- 10 mM
- 0.7803 mL
- 3.9017 mL
- 7.8034 mL

技术信息

CAS号

141-90-2

储存条件

粉末: Inert atmosphere,Room Temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C4H4N2OS

运输

蓝冰

分子量

128.15

别名

2-硫脲嘧啶;Thiouracil;硫尿嘧啶

溶解度

DMSO	50.0 mg/mL (390.2 mM) warming
Water	Insoluble

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