|3-(4-羟基苯基)-1-苯基丙-2-烯-1-酮|CsnPharm

CAS No.: 20426-12-4

4-Hydroxychalcone/4-羟基查耳酮 Catalog No. CSN29071

Synonyms: P-Cinnamoylphenol;4-羟基查耳酮

4-Hydroxychalcone is an intermediate used to synthesize antineoplastic compound.

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技术信息

生物活性

描述4-Hydroxychalcone is a chalcone metabolite with anti-angiogenic and anti-inflammatory activities. The administration of 4-HC (10 mg/kg/day) significantly decreased the number of colon adenomas by 45% and the size of colon adenomas by 35% compared with the respective controls. Similarly, the number of adenomas in the distal small intestine (DSI) and proximal small intestine also decreased by 35 and 33%, respectively, in 4-HC-treated mice, and adenoma size in the DSI decreased by 39% compared with the respective controls. Treatment with 4-HC strongly decreased proliferation in colon and DSI adenomas, as detected by immunofluorescence staining with the proliferation marker protein Ki-67, and promoted apoptosis in colon adenomas, as detected by TUNEL immunofluorescence staining. In addition, decreased mRNA expression of β-catenin target genes, including c-Myc, Axin2 and CD44, in colon adenomas of 4-HC-treated animals demonstrated the involvement of the Wnt/β-catenin signaling pathway in the initiation and progression of colon neoplasms. Treatment with 4-HC also decreased the protein levels of β-catenin in colon adenomas, as demonstrated by immunofluorescence staining^[1]. 4'-hydroxychalcone inhibits TNFα-dependent degradation of IκBα and subsequently prevents p50/p65 nuclear translocation leading to 4'-hydroxychalcone-inhibited expression of NF-κB target genes^[2]. Incubation of cultured SHSY5Y cells with 10-60 μM 4HC (24 h) decreased cell confluency, cellular metabolic activity and depleted intracellular ATP relative to the vehicle-treated control^[3]. When combined with the anticancer drugs cisplatin or doxorubicin, 4-hydroxychalcone led to greater reductions in cell viability than was induced by either anti-cancer agent alone^[4].
参考文献

[1] Chen Q, Lei J, Zhou J, Ma S, Huang Q, Ge B. Chemopreventive effect of 4'-hydroxychalcone on intestinal tumorigenesis in ApcMin mice. Oncol Lett. 2021 Mar;21(3):213
[2] Orlikova B, Tasdemir D, Golais F, Dicato M, Diederich M. The aromatic ketone 4'-hydroxychalcone inhibits TNFα-induced NF-κB activation via proteasome inhibition. Biochem Pharmacol. 2011 Sep 15;82(6):620-31
[3] de Moura Escobar SJ, Simone M, Martin N, de Oliveira Ribeiro CA, Martinez GR, Winnischofer SMB, Witting PK, Rocha MEM. Cytotoxic effects of 4'-hydroxychalcone on human neuroblastoma cells (SH-SY5Y). Toxicol In Vitro. 2019 Dec;61:104640
[4] Alshangiti AM, Tuboly E, Hegarty SV, McCarthy CM, Sullivan AM, O'Keeffe GW. 4-Hydroxychalcone Induces Cell Death via Oxidative Stress in MYCN-Amplified Human Neuroblastoma Cells. Oxid Med Cell Longev. 2019 Dec 5;2019:1670759

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 4.4592 mL
- 22.2961 mL
- 44.5922 mL
- 5 mM
- 0.8918 mL
- 4.4592 mL
- 8.9184 mL
- 10 mM
- 0.4459 mL
- 2.2296 mL
- 4.4592 mL

技术信息

CAS号	20426-12-4	储存条件	粉末 Sealed in dry,Room Temperature 液体 -20°C:3-6 月 -80°C:12月
分子式	C15H12O2	运输	蓝冰
分子量	224.25	别名	P-Cinnamoylphenol;4-羟基查耳酮

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