|3-异丁基-1-甲基-3,7-二氢-1H-嘌呤-2,6-二酮|CsnPharm

CAS No.: 28822-58-4

3-异丁基-1-甲基黄嘌呤 Catalog No. CSN19387

Synonyms: 3-Isobutyl-1-methylxanthine;Isobutylmethylxanthine;IMX

IBMX is a competitive nonselective PDEs inhibitor and a nonselective adenosine receptor antagonist, with IC50 of 2-50 μM but does not inhibit PDE8 or PDE9.

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技术信息

生物活性

描述Phosphodiesterases (PDEs) are enzymes that regulate the function of immune cells by hydrolyzing cyclic guanosine monophosphate/cGMP and cyclic adenosine monophosphate/cAMP. PDEs are divided into subfamilies (PDE3, PDE4, PDE5 and PDE7) which are mainly found in the respiratory tract^[3]. IBMX is a broad-spectrum PDE inhibitor and its IC₅₀ values for PDE3, 4 and 5 were 6.5 ± 1.2, 26.3 ± 3.9 and 31.7 ± 5.3 μM, respectively^[4]. Human proximal tubular epithelial HK-2 cells were treated with different concentrations of IBMX for 24 h to elucidate the effect of IBMX on HIF-1 mRNA expression, IBMX reduced the mRNA levels in a dose dependant manner starting from 400 M concentration. HK-2 cells treated with or without IBMX were exposed to hypoxia for different durations, and cell viability was maintained in IBMX treated group at 24 h and 48 h, and the protective effect became significant at 48 h^[5].
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT02807415	-	-	Recruiting	June 2019	Germany ... more >> Justus-Liebig-University Recruiting Gießen, Germany, 35385 Contact: Lutz Nährlich, MD 004964198557620 lutz.naehrlich@paediat.med.uni-giessen.de Contact: Claudia Rückes-Nilges, Dipl-Biol 004964198556945 claudia.rueckes-nilges@paediat.med.uni-giessen.de Principal Investigator: Lutz Nährlich, MD Sub-Investigator: Stefan Kuhnert, MD Hannover Medical School Recruiting Hannover, Germany, 30625 Contact: Burkhard Tümmler, MD PhD 00495115322920 tuemmler.burkhard@mh-hannover.de Contact: Christian Dopfer, MD 00495115326111 dopfer.christian@mh-hannover.de Principal Investigator: Burkhard Tümmler, MD PhD Sub-Investigator: Christian Dopfer, MD University of Heidelberg Recruiting Heidelberg, Germany, 69120 Contact: Marcus Mall, MD 00496221564502 Marcus.Mall@med.uni-heidelberg.de Contact: Simon Gräber, MD 004962215638926 Simon.Graeber@med.uni-heidelberg.de Principal Investigator: Marcus Mall, MD Sub-Investigator: Simon Gräber, MD Sub-Investigator: Susanne Dittrich, MD Collapse <<
NCT03652090	-	-	Completed	-	-

参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 4.4996 mL
- 22.4978 mL
- 44.9956 mL
- 5 mM
- 0.8999 mL
- 4.4996 mL
- 8.9991 mL
- 10 mM
- 0.4500 mL
- 2.2498 mL
- 4.4996 mL

技术信息

CAS号

28822-58-4

储存条件

粉末: Keep in dark place,Sealed in dry,Store in freezer, under -20°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C10H14N4O2

运输

蓝冰

分子量

222.24

别名

3-Isobutyl-1-methylxanthine;Isobutylmethylxanthine;IMX;Methylisobutylxanthine;1-Methyl-3-Isobutylxanthine;NSC 165960;SC-2964;3-异丁基-1-甲基黄嘌呤

溶解度

DMSO	42.0 mg/mL (189.0 mM)
Water	Insoluble
Ethanol	7.0 mg/mL (31.5 mM)

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