|3-溴丙酮酸|CsnPharm

CAS No.: 1113-59-3

3-溴丙酮酸 Catalog No. CSN12486

Synonyms: Bromopyruvic acid;Hexokinase II Inhibitor II, 3-BP;3-Bromopyruvate

3-Bromopyruvic acid is an inhibitor of hexokinase II with effective antitumor acitvity.

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靶点选择性

生物活性

实验方案

技术信息

生物活性

描述3-Bromopyruvate (3-BrPA) is an analogue of pyruvate and a potent hexokinase (HK)-II inhibitor with high tumor selectivity. 3-BrPA can induce growth inhibition in a dose-dependent pattern by cell apoptosis. 3-BrPA combined with rapamycin played a synergistic suppression role in NB cells, affected the cell apoptosis, cell cycle and the metabolic pathway^[3]. Low concentration of 3-BrPA significantly affected both glutaminolysis and TCA cycle functions, through inhibition of isocitrate dehydrogenase, α-ketoglutarate dehydrogenase and succinate dehydrogenase. Additionally, 3-BrPA treatment significantly decreased the reduced status of thiol groups in HepG2 cells without proportional increase of oxidizing groups, suggesting that these chemical groups are the target of alkylation reactions induced by 3-BrPA^[4]. 3-BrPA synergistically sensitized breast cancer cells to TRAIL‑induced apoptosis via the upregulation of death receptor 5 (DR5). And the protein levels of glucose‑related protein 78 (GRP78) and CCAAT‑enhancer‑binding protein homologous protein (CHOP) increased following treatment with 3-BrPA. 3-BrPA sensitized breast cancer cells to TRAIL via the AMPK (adenosine monophosphate-activated protein kinase)-mediated upregulation of DR5^[5].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 5.9895 mL
- 29.9476 mL
- 59.8953 mL
- 5 mM
- 1.1979 mL
- 5.9895 mL
- 11.9791 mL
- 10 mM
- 0.5990 mL
- 2.9948 mL
- 5.9895 mL

技术信息

CAS号

1113-59-3

储存条件

粉末: Sealed in dry,Store in freezer, under -20°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C3H3BrO3

运输

蓝冰

分子量

166.96

别名

Bromopyruvic acid;Hexokinase II Inhibitor II, 3-BP;3-Bromopyruvate;Hexokinase II Inhibitor II;3-BP;3-Bromopyruvic Acid;β-Bromopyruvic acid;NSC 11731;NSC 62343;3-溴丙酮酸

溶解度

DMSO	31.0 mg/mL (185.7 mM)

动物实验配方

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3-溴丙酮酸 Catalog No. CSN12486

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