|3-(哌啶-2-基)吡啶|CsnPharm

CAS No.: 13078-04-1

八角枫碱 Catalog No. CSN16831

Synonyms: 八角枫碱;2-吡啶-3-哌啶

Anabasine is a pyridine and piperidine alkaloid found in the tree tobacco plant, a close relative of the common tobacco plant.

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靶点选择性

生物活性

实验方案

技术信息

生物活性

描述Anabasine is a nicotinic receptor agonist. In the radial-arm maze memory test, anabasine but not anatabine significantly reduced the memory impairment caused by the NMDA antagonist dizocilpine (MK-801)^[3]. The differences among does in fetal movements were more consistent at dosing and following recovery for doses of anabasine above 0.125 mg/kg compared to the other compounds and dosages. Anabasine actions were dose-dependent with an IC50 value of ∼0.1 mg/kg, and, at a dose of 0.8 mg/kg, completely inhibited fetal movement for 1.5 h after dosing^[4]. However, the use of anabasine as an insecticide, and its presence in consumables other than nicotine products, suggests that anabasine may not be specific to tobacco use/exposure^[5].
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT02347787	Hypertension ... more >>Diabetes Obesity Tobacco Dependence Collapse <<	Not Applicable	Active, not recruiting	July 2018	-
NCT02606227	Pregnancy Smo... more >>king Collapse <<	Not Applicable	Recruiting	December 2019	France ... more >> Groupe Hospitalier Pitié-Salpétrière Recruiting Paris, France, 75013 Contact: BERLIN Ivan Collapse <<
NCT03276780	Smoking Cessation	Phase 4	Recruiting	August 31, 2020	United States, Alabama ... more >> University of Alabama at Birmingham Recruiting Birmingham, Alabama, United States, 35294 Contact: Michelle Sisson, M.A. 205-975-7809 msisson2@uab.edu Contact: Samantha Schiavon, M.A. 205-975-4528 sschiavon@uabmc.edu Principal Investigator: Karen Cropsey, Psy.D. Sub-Investigator: Richard Shelton, M.D. Sub-Investigator: Peter Hendricks, Ph.D. Collapse <<

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参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 6.1640 mL
- 30.8201 mL
- 61.6403 mL
- 5 mM
- 1.2328 mL
- 6.1640 mL
- 12.3281 mL
- 10 mM
- 0.6164 mL
- 3.0820 mL
- 6.1640 mL

技术信息

CAS号

13078-04-1

储存条件

粉末: Keep in dark place,Inert atmosphere,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C10H14N2

运输

蓝冰

分子量

162.23

别名

八角枫碱;2-吡啶-3-哌啶

溶解度

DMSO	130.0 mg/mL (801.3 mM) warming

动物实验配方

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NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点

NCT02347787	Hypertension ... more >>Diabetes Obesity Tobacco Dependence Collapse <<	Not Applicable	Active, not recruiting	July 2018	-
NCT02606227	Pregnancy Smo... more >>king Collapse <<	Not Applicable	Recruiting	December 2019	France ... more >> Groupe Hospitalier Pitié-Salpétrière Recruiting Paris, France, 75013 Contact: BERLIN Ivan Collapse <<
NCT03276780	Smoking Cessation	Phase 4	Recruiting	August 31, 2020	United States, Alabama ... more >> University of Alabama at Birmingham Recruiting Birmingham, Alabama, United States, 35294 Contact: Michelle Sisson, M.A. 205-975-7809 msisson2@uab.edu Contact: Samantha Schiavon, M.A. 205-975-4528 sschiavon@uabmc.edu Principal Investigator: Karen Cropsey, Psy.D. Sub-Investigator: Richard Shelton, M.D. Sub-Investigator: Peter Hendricks, Ph.D. Collapse <<
NCT03379025	COPD Tobacco ... more >>Use Collapse <<	Not Applicable	Not yet recruiting	August 2021	-
NCT02244918	Smoking Cessation	Phase 4	Completed	-	United States, Kansas ... more >> University of Kansas Medical Center Kansas City, Kansas, United States, 66160 United States, Missouri Swope Health Central Kansas City, Missouri, United States, 64130 Collapse <<
NCT01018394	Tobacco Dependence	Phase 2 Phase 3	Completed	-	United States, Minnesota ... more >> Mayo Clinic Rochester, Minnesota, United States, 55905 United States, Oregon Oregon Research Institute Eugene, Oregon, United States, 97403 Collapse <<
NCT01018394	-	-	Completed	-	-
NCT01413516	Smoking Cessation	Phase 2	Completed	-	United States, California ... more >> Stanford Hospital and Clinics Stanford, California, United States, 94305 Collapse <<
NCT02478697	Tobacco Dependence	Not Applicable	Recruiting	August 2019	United States, California ... more >> JobTrain Recruiting Menlo Park, California, United States, 94025 Contact: Cati Brown-Johnson, PhD 650-721-1846 San Francisco Employment Development Department Recruiting San Francisco, California, United States, 94102 Contact: Cati Brown-Johnson, PhD 650-721-1846 Marin Employment Connection Recruiting San Rafael, California, United States, 94903 Contact: Cati Brown-Johnson, PhD 650-721-1846 Collapse <<
NCT01413516	-	-	Completed	-	-
NCT03589989	Smoking Cessation	Not Applicable	Recruiting	June 2020	Switzerland ... more >> Policlinique Médicale Universitaire, Université de Lausanne Not yet recruiting Lausanne, Vaud, Switzerland, 1011 Contact: Jacques Cornuz, Prof.Dr.med Jacques.Cornuz@chuv.ch University Clinic for General Internal Medicine, Bern University Hospital Recruiting Bern, Switzerland, 3010 Contact: Nicolas Rodondi, Prof.Dr.med Nicolas.Rodondi@insel.ch Département de médecine interne, Hôpitaux universitaires de Genève Not yet recruiting Geneva, Switzerland, 1211 Contact: Jean-Paul Humair, PD Dr.med. Jean-Paul.Humair@hcuge.ch Collapse <<
NCT03473483	Nicotine Dependence ... more >> Tobacco Toxicity Nicotine Dependence, Cigarettes Cardiovascular Risk Factor Nicotine Withdrawal Collapse <<	Not Applicable	Not yet recruiting	June 1, 2020	United States, California ... more >> UCSF Tobacco Research Center Not yet recruiting San Francisco, California, United States, 94110 Contact: Lisa Harms 415-608-4864 lisa.harms@ucsf.edu Contact: Natalie Nardone, PhD (415) 514-1450 natalie.nardone@ucsf.edu Principal Investigator: Neal L Benowitz, MD Zuckerberg San Francisco General Hospital - CTSI San Francisco, California, United States, 94110 Collapse <<
NCT00939029	Smokeless Tobacco Use	Phase 2 Phase 3	Completed	-	United States, Minnesota ... more >> Mayo Clinic Rochester, Minnesota, United States, 55905 Collapse <<
NCT00939029	-	-	Completed	-	-
NCT01526265	Tobacco Use Disorder	Not Applicable	Completed	-	United States, Pennsylvania ... more >> University of Pennsylvania Philadelphia, Pennsylvania, United States, 19104 Collapse <<
NCT01303081	Tobacco Use Disorder	Not Applicable	Completed	-	United States, Pennsylvania ... more >> University of Pennsylvania Philadelphia, Pennsylvania, United States, 19104 Collapse <<

八角枫碱 Catalog No. CSN16831

靶点选择性

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