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CAS No.: 10347-81-6

盐酸马普替林 Catalog No. CSN11360

Synonyms: Maprotiline (hydrochloride) (CRM);Ba 34276;Maprotiline Hydrochlorine

Maprotiline HCl is a bridged-ring tetracyclic antidepressant with adrenergic activity and sedative properties, exerting its effect by blocking the re-uptake of norepinephrine, thereby increasing the synaptic concentration of norepinephrine in the central nervous system and subsequently prolonging the action of norepinephrine on central receptors.

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技术信息

生物活性

描述Maprotiline (Hydrochloride), selective NA reuptake inhibitor, a tetracyclic antidepressant with sedative properties, exhibits strong inhibitory effects on norepinephrine uptake across nerve cell membranes but interferes relatively little with serotoninergic mechanisms^[3]. Maprotiline bounds to the full-length recombinant sGC (Soluble guanylate cyclase) with a high affinity (KD = 0.307 μM). Moreover, in a monocrotaline rat model of PAH (Pulmonary arterial hypertension), maprotiline (ip, 10 mg/kg once daily) reduced pulmonary hypertension, inhibited the development of right ventricular hypertrophy and pathological changes of the pulmonary vascular remodeling^[4].
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT02873234	-	-	Recruiting	May 2020	China, Beijing ... more >> The Third Affiliated Hospital of Beijing University of Chinese Medicine Recruiting Beijing, Beijing, China, 100029 Contact: Wenjun Sun, MD, PHD +86 18910259376 doctorsunwenjun@126.com Collapse <<
NCT02374567	Dementia Depr... more >>ession Schizophrenia Psychosomatic Disorders Anxiety Disorders Collapse <<	Phase 3	Terminated	-	Germany ... more >> Bezirkskrankenhaus Augsburg Augsburg, Germany Krankenhaus Hedwigshöhe Berlin, Germany Hannover Medical School Hannover, Germany, 30625 Asklepios Fachklinikum Lübben Lübben, Germany Asklepios Fachklinikum Teupitz Teupitz, Germany Collapse <<
NCT00704860	Major Depression	Phase 4	Completed	-	Canada, Ontario ... more >> University of Ottawa Institute of Mental Health Research Ottawa, Ontario, Canada, K1Z 7K4 Collapse <<

更多
参考文献

[1] Ferrer-Villada T, Navarro-Polanco RA, et al. Inhibition of cardiac HERG potassium channels by antidepressant maprotiline. Eur J Pharmacol. 2006 Feb 15;531(1-3):1-8.
[2] Arenas MC, Vinader-Caerols C, et al. Are the effects of the antidepressants amitriptyline, maprotiline, and fluoxetine on inhibitory avoidance state-dependent? Behav Brain Res. 2006 Jan 6;166(1):150-8.
[3] Wells BG, Gelenberg AJ. Chemistry, pharmacology, pharmacokinetics, adverse effects, and efficacy of the antidepressant maprotiline hydrochloride. Pharmacotherapy. 1981 Sep-Oct;1(2):121-39.
[4] Tong Y, Jiao Q, Liu Y, Lv J, Wang R, Zhu L. Maprotiline Prevents Monocrotaline-Induced Pulmonary Arterial Hypertension in Rats. Front Pharmacol. 2018 Sep 21;9:1032.

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 3.1861 mL
- 15.9305 mL
- 31.8609 mL
- 5 mM
- 0.6372 mL
- 3.1861 mL
- 6.3722 mL
- 10 mM
- 0.3186 mL
- 1.5930 mL
- 3.1861 mL

技术信息

CAS号

10347-81-6

储存条件

粉末: Inert atmosphere,Room Temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C20H24ClN

运输

蓝冰

分子量

313.86

别名

Maprotiline (hydrochloride) (CRM);Ba 34276;Maprotiline Hydrochlorine;Maprotiline Hcl;Psymion;Ludiomil;Maprotilline HCl;Teva Brand of Maprotiline Hydrochloride;盐酸马普替林

溶解度

DMSO	68.0 mg/mL (216.7 mM)
Water	insoluble

动物实验配方

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NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点

NCT02873234	-	-	Recruiting	May 2020	China, Beijing ... more >> The Third Affiliated Hospital of Beijing University of Chinese Medicine Recruiting Beijing, Beijing, China, 100029 Contact: Wenjun Sun, MD, PHD +86 18910259376 doctorsunwenjun@126.com Collapse <<
NCT02374567	Dementia Depr... more >>ession Schizophrenia Psychosomatic Disorders Anxiety Disorders Collapse <<	Phase 3	Terminated	-	Germany ... more >> Bezirkskrankenhaus Augsburg Augsburg, Germany Krankenhaus Hedwigshöhe Berlin, Germany Hannover Medical School Hannover, Germany, 30625 Asklepios Fachklinikum Lübben Lübben, Germany Asklepios Fachklinikum Teupitz Teupitz, Germany Collapse <<
NCT00704860	Major Depression	Phase 4	Completed	-	Canada, Ontario ... more >> University of Ottawa Institute of Mental Health Research Ottawa, Ontario, Canada, K1Z 7K4 Collapse <<
NCT02374567	Dementia Depr... more >>ession Schizophrenia Psychosomatic Disorders Anxiety Disorders Collapse <<	Phase 3	Terminated	-	Germany ... more >> Bezirkskrankenhaus Augsburg Augsburg, Germany Krankenhaus Hedwigshöhe Berlin, Germany Hannover Medical School Hannover, Germany, 30625 Asklepios Fachklinikum Lübben Lübben, Germany Asklepios Fachklinikum Teupitz Teupitz, Germany Collapse <<
NCT00704860	Major Depression	Phase 4	Completed	-	Canada, Ontario ... more >> University of Ottawa Institute of Mental Health Research Ottawa, Ontario, Canada, K1Z 7K4 Collapse <<
NCT02873234	-	-	Recruiting	May 2020	China, Beijing ... more >> The Third Affiliated Hospital of Beijing University of Chinese Medicine Recruiting Beijing, Beijing, China, 100029 Contact: Wenjun Sun, MD, PHD +86 18910259376 doctorsunwenjun@126.com Collapse <<

盐酸马普替林 Catalog No. CSN11360

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