CAS No.: 552-66-9
大豆苷 Catalog No. CSN16397
Synonyms: Daidzoside;NPI-031D;Daidzein 7-O-glucoside
Daidzin can inhibit mitochondrial aldehyde dehydrogenase2 with IC50 of 80 nM and ALDH-I selectively (Ki=20 nM). Daidzin is purified from the root of Pueraria lobata with effective anti-atherosclerotic activities.
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纯度 & 质量文件
批次:
靶点选择性
生物活性
- 描述
- 临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点 NCT03099590 Alcohol Drinking ... more >> Alcohol Use Disorder Alcohol Abstinence Collapse << Phase 2 Recruiting March 1, 2020 United States, Massachusetts ... more >> McLean Hospital Recruiting Belmont, Massachusetts, United States, 02478 Contact: Scott E Lukas, PhD 617-855-2767 Slukas@mclean.harvard.edu Contact: Wendy Tartarini, MA 617-855-2174 Wtartarini@mclean.harvard.edu Collapse << NCT02309801 Healthy Phase 1 Completed - Spain ... more >> Parc de Salut Mar. Barcelona, Spain, 08003 Collapse << - 参考文献
- [1] Keung WM, Vallee BL. Kudzu root: an ancient Chinese source of modern antidipsotropic agents. Phytochemistry. 1998 Feb;47(4):499-506.
- [2] Keung WM, Vallee BL. Daidzin: a potent, selective inhibitor of human mitochondrial aldehyde dehydrogenase. Proc Natl Acad Sci U S A. 1993 Feb 15;90(4):1247-51.
- [3] Keung WM, Klyosov AA, Vallee BL. Daidzin inhibits mitochondrial aldehyde dehydrogenase and suppresses ethanol intake of Syrian golden hamsters. Proc Natl Acad Sci U S A. 1997 Mar 4;94(5):1675-9
- [4] Xie CI, Lin RC, Antony V, Lumeng L, Li TK, Mai K, Liu C, Wang QD, Zhao ZH, Wang GF. Daidzin, an antioxidant isoflavonoid, decreases blood alcohol levels and shortens sleep time induced by ethanol intoxication. Alcohol Clin Exp Res. 1994 Dec;18(6):1443-7
- [5] Xiao F, Cui H, Zhong X. Beneficial effect of daidzin in dry eye rat model through the suppression of inflammation and oxidative stress in the cornea. Saudi J Biol Sci. 2018 May;25(4):832-837
- [6] Wu KC, Lin WY, Sung YT, Wu WY, Cheng YH, Chen TS, Chiang BJ, Chien CT. Glycine tomentella hayata extract and its ingredient daidzin ameliorate cyclophosphamide-induced hemorrhagic cystitis and oxidative stress through the action of antioxidation, anti-fibrosis, and anti-inflammation. Chin J Physiol. 2019 Sep-Oct;62(5):188-195
- [7] Keung WM, Lazo O, Kunze L, Vallee BL. Daidzin suppresses ethanol consumption by Syrian golden hamsters without blocking acetaldehyde metabolism. Proc Natl Acad Sci U S A. 1995 Sep 12;92(19):8990-3
- [8] Keung WM, Vallee BL. Daidzin: a potent, selective inhibitor of human mitochondrial aldehyde dehydrogenase. Proc Natl Acad Sci U S A. 1993 Feb 15;90(4):1247-51
实验方案
- 计算器
- 储存液制备
技术信息
| CAS号 | 552-66-9 | 储存条件 |
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| 分子式 | C21H20O9 | 运输 | 蓝冰 | |||||
| 分子量 | 416.38 | 别名 | Daidzoside;NPI-031D;Daidzein 7-O-glucoside;大豆苷 | |||||
| 溶解度 |
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动物实验配方 |
