|3-(3-乙基六氢-1-甲基-1H-氮杂卓-3-基)苯酚盐酸盐|CsnPharm

CAS No.: 59263-76-2

盐酸美普他酚 Catalog No. CSN11381

Synonyms: IL-22811 HCl;Meptazinol Hydrochloride;IL-22811

Meptazinol HCl is both a partial agonist of μ1 opioid receptor and an AChE inhibitor.

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技术信息

生物活性

描述Meptazinol Hydrochloride (Meptazinol) is a new opioid-type analgesic with mixed agonist/antagonist properties. It may be given orally, intravenously or intramuscularly^[3]. Meptazinol is an agonist-antagonist opioid analgesic believed to be unique in its selectivity for mu1 (high affinity) receptors and its cholinergic activity^[4]. Meptazinol inhibits a portion of 3H-labeled opiate and opioid peptide binding quite potently, with IC50 value under 1 nM^[5]. Meptazinol and its isomers have anti-nociceptive and anti-hyperalgesic properties with the former more potent. The effects are mainly mediated by mu opioid receptors^[6]. The intravenous administration, to anaesthetized rats, of meptazinol (1 and 2 mg kg-1), a partial agonist at opiate receptors, greatly reduced the incidence of ventricular extrasystoles that resulted from acute coronary artery occlusion. Moreover, pretreatment with meptazinol (1 and 2 mg kg-1) also reduced ventricular arrhythmias, including fibrillation, in conscious rats subjected to coronary artery occlusion^[7].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 3.7063 mL
- 18.5315 mL
- 37.0631 mL
- 5 mM
- 0.7413 mL
- 3.7063 mL
- 7.4126 mL
- 10 mM
- 0.3706 mL
- 1.8532 mL
- 3.7063 mL

技术信息

CAS号

59263-76-2

储存条件

粉末: Inert atmosphere,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C15H24ClNO

运输

蓝冰

分子量

269.81

别名

IL-22811 HCl;Meptazinol Hydrochloride;IL-22811;WY-22811;WY22811. trade name Meptid

溶解度

DMSO	85.0 mg/mL (315.0 mM)

动物实验配方

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盐酸美普他酚 Catalog No. CSN11381

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