|3-(2-羟基-2,2-二苯乙氧基)-1,1-二甲基哌啶-1-溴化铵|CsnPharm

CAS No.: 76-90-4

溴美喷酯 Catalog No. CSN11378

Synonyms: Mepenzolate (bromide);NSC 4358;Mepenzolate Bromide

Mepenzolate bromide mAchR antagonist, working as a post-ganglionic parasympathetic inhibitor to decrease gastric acid and pepsin secretion and suppresse spontaneous contractions of the colon.

规格	价格	促销价格	库存	数量

400-920-2911

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技术信息

生物活性

描述Mepenzolate bromide (MP), an antagonist for human muscarinic M3 receptor (hM3R), has both anti-inflammatory and short-acting bronchodilatory activities^[3]. Mepenzolate bromide, used to treat gastrointestinal disorders in clinical settings, also displayed beneficial effects in chronic obstructive pulmonary disease and pulmonary fibrosis of a mouse model by inhibiting inflammatory responses and reducing oxidative stress^[4]. Apart from suppressing elastase-induced pulmonary inflammatory responses and the production of superoxide anions, mepenzolate bromide reduces the level of cigarette smoke-induced airspace enlargement and respiratory dysfunction. Mpenzolate bromide may be an effective therapeutic for the treatment of COPD (chronic obstructive pulmonary disease) due to its anti-inflammatory and bronchodilatory activities^[5]. The intratracheal administration of mepenzolate reduced bleomycin-induced pulmonary fibrosis and lung dysfunction in mice^[6].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.3790 mL
- 11.8951 mL
- 23.7903 mL
- 5 mM
- 0.4758 mL
- 2.3790 mL
- 4.7581 mL
- 10 mM
- 0.2379 mL
- 1.1895 mL
- 2.3790 mL

技术信息

CAS号

76-90-4

储存条件

粉末: Inert atmosphere,Room Temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C21H26BrNO3

运输

蓝冰

分子量

420.34

别名

Mepenzolate (bromide);NSC 4358;Mepenzolate Bromide;Cantil;Gastropidil;Cantilaque;Cantilon;mepenzolate iodide;mepenzolic acid;溴美喷酯;溴化甲哌佐酯

溶解度

DMSO	270.0 mg/mL (642.3 mM)
Water	insoluble

动物实验配方

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