|3,5,7-三羟基-2-(4-羟基-3-甲氧基苯基)-4H-苯并吡喃-4-酮|CsnPharm

CAS No.: 480-19-3

异鼠李素 Catalog No. CSN12677

Synonyms: 3'-Methylquercetin;3'-O-methyl Quercetin;4H-1-Benzopyran-4-one

Isorhamnetin, a natural flavonol aglycone, can inhibit xanthine oxidase with IC50 of 400nM and stabilize β-catenin as well as up-regulate the Wnt signaling pathway. Isorhamnetin could also be act as an apoptosia inducer with antitumor activities.

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400-920-2911

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技术信息

生物活性

描述Isorhamnetin, a flavonoid compound extracted from the Chinese herb Hippophae rhamnoides L., is well known for its anti-inflammatory, anti-oxidative, anti-adipogenic, anti-proliferative, and anti-tumor activities. Isorhamnetin could inhibit cardiac hypertrophy and fibrosis 8 weeks after aortic banding. In vitro studies performed in neonatal rat cardiomyocytes confirmed that isorhamnetin could attenuate cardiomyocyte hypertrophy induced by angiotensin II, which was associated with phosphatidylinositol 3-kinase-AKT signaling pathway^[3]. Isorhamnetin inhibited epidermal growth factor (EGF)-induced neoplastic cell transformation. Isorhamnetin attenuated EGF-induced COX-2 expression in JB6 and A431 cells. In an in vivo mouse xenograft using A431 cells, isorhamnetin reduced tumor growth and COX-2 expression^[4]. Isorhamnetin inhibits the proliferation of numerous breast cancer cells (IC50, ~10 µM), including MCF7, T47D, BT474, BT-549, MDA-MB-231 and MDA-MB-468, whereas less inhibitory activity is observed in the MCF10A normal breast epithelial cell line (IC50, 38 µM) ^[5]. Isorhamnetin inhibits the TGF-β/Smad signaling pathway and relieves oxidative stress, thus inhibiting HSC (hepatic stellate cells) activation and preventing liver fibrosis^[6].
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT02627547	Healthy	Not Applicable	Completed	-	United Kingdom ... more >> University of Glasgow School of Medicine Glasgow, United Kingdom Collapse <<
NCT02425436	Intrauterine Growth Restrictio... more >>n (IUGR) Collapse <<	Phase 2	Completed	-	-

参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 3.1619 mL
- 15.8097 mL
- 31.6193 mL
- 5 mM
- 0.6324 mL
- 3.1619 mL
- 6.3239 mL
- 10 mM
- 0.3162 mL
- 1.5810 mL
- 3.1619 mL

技术信息

CAS号

480-19-3

储存条件

粉末: Sealed in dry,Room Temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C16H12O7

运输

蓝冰

分子量

316.26

别名

3'-Methylquercetin;3'-O-methyl Quercetin;4H-1-Benzopyran-4-one;2-(3-methoxy-4-hydroxyphenyl)-3,5,7-trihydroxy-;3-Methylquercetin;Quercetin;异鼠李素

溶解度

DMSO	63.0 mg/mL (199.2 mM)

动物实验配方

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