CAS No.: 20380-11-4
27-Hydroxycholesterol/27-羟基胆固醇 Catalog No. CSN20272
Synonyms: 25(R)-27-hydroxy Cholesterol;(25R)-26-hydroxy Cholesterol;27-HC
27-Hydroxycholesterol is an endogenous oxysterol with multiple biological functions, including activity as a selective estrogen receptor modulator (SERM) (a mixed, tissue-specific agonist-antagonist of the estrogen receptor (ER)) and as an agonist of the liver X receptor (LXR). It is a metabolite of cholesterol that is produced by the enzyme CYP27A1.
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纯度 & 质量文件
批次:
靶点选择性
生物活性
- 描述
- 临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点 NCT03525184 Sleep Restriction Not Applicable Recruiting December 2019 United States, Massachusetts ... more >> U.S. Army Research Institute of Environmental Medicine Recruiting Natick, Massachusetts, United States, 01760 Contact: Tracey J Smith, PhD 508-233-4868 tracey.smith10.civ@mail.mil Collapse << NCT02259153 Lipid Metabolism Disorders ... more >> Sterols Diet, High-Fat Cholesterol Fatty Acids Hyperlipidemias Collapse << Not Applicable Completed - - NCT01180361 - - Recruiting December 2018 United States, New York ... more >> Winthrop University Hospital Recruiting Mineola, New York, United States, 11501 Contact: Steven Carsons, MD 516-663-4751 SCarsons@winthrop.org Principal Investigator: Allison B Reiss, MD Sub-Investigator: Steven Carsons, MD Collapse << - 更多
- 参考文献
- [1] Alfaqih MA, Nelson ER, et al. CYP27A1 Loss Dysregulates Cholesterol Homeostasis in Prostate Cancer. Cancer Res. 2017 Apr 1;77(7):1662-1673.
- [2] Cedo L, Garcia-Leon A, et al. ApoA-I mimetic administration, but not increased apoA-I-containing HDL, inhibits tumour growth in a mouse model of inherited breast cancer. Sci Rep. 2016 Nov 3;6:36387.
实验方案
- 计算器
- 储存液制备
技术信息
| CAS号 | 20380-11-4 | 储存条件 |
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| 分子式 | C27H46O2 | 运输 | 蓝冰 | |
| 分子量 | 402.65 | 别名 | 25(R)-27-hydroxy Cholesterol;(25R)-26-hydroxy Cholesterol;27-HC;27-羟基胆固醇 |
