|20(R)-人参皂苷 RH2|CsnPharm

CAS No.: 112246-15-8

20(R)-Ginsenoside Rh2/20（R）-人参皂甙Rh2 Catalog No. CSN19878

Synonyms: FG73845;20(R)-人参皂苷Rh2

20(R)-Ginsenoside Rh2 has anticancer effects and can increase inchoate apoptotic rate, reduce apoptotic rate significantly, enhance the activity of caspase-3 and induces apoptosis in human lung adenocarcinoma A549 cells. It is a natural product isolated and purified from the roots of Panax ginseng C. A. Mey..

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描述20(R)-Ginsenoside Rh2, a matrix metalloproteinase (MMP) inhibitor, acts as a cell antiproliferator. It has anticancer effects via blocking cell proliferation and causing G1 phase arrest. 20(R)-Rh2 was able to suppress NO, PGE2, ROS and pro-matrix metalloproteinase-9 (pro-MMP-9) levels that were enhanced in the LPS-stimulated murine RAW264.7 macrophage cells. 20(R)-Rh2 also exhibited inhibitory effects on the level of ROS and the activity of MMP-9 and -2 in human HaCat keratinocyte cells without stimulant exposure. 20(R)-Rh2 could suppress the gelatinolytic activity of MMP-9 enhanced by tumour necrosis factor-α in the keratinocytes^[3]. 20(R)-Ginsenoside Rh2 inhibited the replication and proliferation of murine gammaherpesvirus 68 (MHV-68), and its half-maximal inhibitory concentration (IC50) against MHV-68 was estimated to be 2.77 μM^[4]. Only ginsenoside 20(R)-Rh2 showed selective osteoclastgenesis inhibitory activity without any cytotoxicity up to 100 microM^[5].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 1.6055 mL
- 8.0273 mL
- 16.0546 mL
- 5 mM
- 0.3211 mL
- 1.6055 mL
- 3.2109 mL
- 10 mM
- 0.1605 mL
- 0.8027 mL
- 1.6055 mL

技术信息

CAS号

112246-15-8

储存条件

粉末: Sealed in dry,Room Temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C36H62O8

运输

蓝冰

分子量

622.87

别名

FG73845;20(R)-人参皂苷Rh2

溶解度

DMSO	100.0 mg/mL (160.5 mM)

动物实验配方

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20(R)-Ginsenoside Rh2/20（R）-人参皂甙Rh2 Catalog No. CSN19878

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