CAS No.: 85122-21-0
2-Methoxystypandrone Catalog No. CSN14687
2-Methoxystypandrone, a natural product isolated and purified from the roots of Polygonum cuspidatum, displays an immunomodulatory effect in a cellular model, specifically inhibits JAK and IKKβ kinase activities, blocks inflammatory responses by impairing NF-κB signaling to limit the inflammation and oxidative stress for preservation of BBB integrity, concomitantly promotes neurodevelopmental protein expression and endogenous neurogenesis through inactivation of GSK3β to enhance β-catenin signaling for upexpression of neuroprotective genes and proteins, and has anti-osteoclastogenic effect, could reflect the block of RANKL-induced association of TRAF6-TAK1 complexes with consequent decrease of IkappaB-mediated NF-kappaB and mitogen-activated protein kinases-mediated c-Fos activation pathways and suppression of NFATc1 and other gene expression, essential for bone resorption.
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生物活性
- 描述
- 参考文献
- [1] Kuang S, Qi C, et al. 2-Methoxystypandrone inhibits signal transducer and activator of transcription 3 and nuclear factor-κB signaling by inhibiting Janus kinase 2 and IκB kinase. Cancer Sci. 2014 Apr;105(4):473-80.
- [2] Chern CM, Wang YH, et al. 2-Methoxystypandrone ameliorates brain function through preserving BBB integrity and promoting neurogenesis in mice with acute ischemic stroke. Biochem Pharmacol. 2014 Feb 1;87(3):502-14.
实验方案
- 计算器
- 储存液制备
技术信息
| CAS号 | 85122-21-0 | 储存条件 |
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| 分子式 | C14H12O5 | 运输 | 蓝冰 | |
| 分子量 | 260.24 | 别名 |
