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CAS No.: 14919-77-8

盐酸苄丝肼 Catalog No. CSN13735

Synonyms: Serazide;Ro 4-4602;Benserazide (hydrochloride)

Benserazide HCl is a aromatic L-amino acid decarboxylase (AAAD) or DOPA decarboxylase inhibitor.

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技术信息

生物活性

描述Benserazide hydrochloride is commonly used in Parkinson's disease and is an inhibitor of peripheral aromatic L-amino acid decarboxylase (AADC). Benserazide reduces the central AADC activity in the striatum of rats with nigrostriatal denervation, which leads to changes in the metabolism of exogenous L-DOPA^[2]. Benserazide hydrochloride (BH) and Levodopa (LD) individually and in combination (BH + LD) (25 μM; 0 hour, 12 hours, 24 hours and 168 hours; SH-SY5Y) treatment inhibit protein aggregation and have the ability to minimise the amyloid-induced cytotoxicity in human neuroblastoma cell line. Benserazide hydrochloride and LD both can act as efficient inhibitors of the formation of cytotoxic HSA aggregates, and the inhibitory effects are more pronounced when both of these drugs are added simultaneously^[3]. Under dopaminergic nigrostriatal denervation, treatment with L-DOPA/BE ameliorated colonic motility through a normalization of myenteric cholinergic neurotransmission, along with an improvement of colonic inflammation^[4].
参考文献

[1] Shen H, Kannari K, et al. Effects of benserazide on L-DOPA-derived extracellular dopamine levels and aromatic L-amino acid decarboxylase activity in the striatum of 6-hydroxydopamine-lesioned rats. Tohoku J Exp Med. 2003 Mar;199(3):149-59.
[2] Shen H, Kannari K, Yamato H, Arai A, Matsunaga M. Effects of benserazide on L-DOPA-derived (L-3,4-dihydroxyphenylalanine) extracellular dopamine levels and aromatic L-amino acid decarboxylase activity in the striatum of 6-hydroxydopamine-lesioned rats. Tohoku J Exp Med. 2003 Mar;199(3):149-59
[3] Chandel TI, Zaidi N, Zaman M, Jahan I, Masroor A, Siddique IA, Nayeem SM, Ali M, Uversky VN, Khan RH. A multiparametric analysis of the synergistic impact of anti-Parkinson's drugs on the fibrillation of human serum albumin. Biochim Biophys Acta Proteins Proteom. 2019 Mar;1867(3):275-285
[4] Pellegrini C, Antonioli L, Colucci R, Tirotta E, Gentile D, Ippolito C, Segnani C, Levandis G, Cerri S, Blandini F, Barocelli E, Ballabeni V, Bernardini N, Blandizzi C, Fornai M. Effects of L-DOPA/benserazide co-treatment on colonic excitatory cholinergic motility and enteric inflammation following dopaminergic nigrostriatal neurodegeneration. Neuropharmacology. 2017 Sep 1;123:22-33

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 3.4048 mL
- 17.0239 mL
- 34.0479 mL
- 5 mM
- 0.6810 mL
- 3.4048 mL
- 6.8096 mL
- 10 mM
- 0.3405 mL
- 1.7024 mL
- 3.4048 mL

技术信息

CAS号

14919-77-8

储存条件

粉末: Keep in dark place,Inert atmosphere,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C10H16ClN3O5

运输

蓝冰

分子量

293.70

别名

Serazide;Ro 4-4602;Benserazide (hydrochloride);盐酸苄丝肼

溶解度

DMSO	60.0 mg/mL (204.3 mM)
Water	150.0 mg/mL (510.7 mM)

动物实验配方

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