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CAS No.: 62613-82-5

奥拉西坦 Catalog No. CSN19514

Synonyms: ISF2522;CGP 21690E;Neuractiv

Oxiracetam is a derivative of gamma-aminobutyric acid (GABA) and used as a nootropic drug to improve memory and learning.

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400-920-2911

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技术信息

生物活性

描述Oxiracetam is a cyclic derivative of γ-aminobutyric acid (GABA) which has been commonly used as nootropic drug to treat cognitive impairments^[3]. Rats were administered with propionic acid (250 mg/kg p.o.) for 3 days and immediately on next day treatment were given with oxiracetam (25, 50 mg/kg i.p), zinc (4 mg/kg) as well as oxiracetam (25 mg/kg i.p) in combination with zinc (4 mg/kg p.o). Treatment with oxiracetam alone and in combination with zinc significantly attenuated behavioral, biochemical, inflammatory cytokines and restored neurotransmitters level^[4]. ORC (oxiracetam) suppressed the activation of BV2 cells, decreased the production of Aβ-induced inflammatory molecules and NO in BV2 cells, and protected HT22 cells against indirect toxicity mediated by Aβ-treated BV2 cell-conditioned medium. Thus, ORC may exert a protective role in AD through attenuating the damage caused by inflammation and oxidative stress^[5].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 6.3229 mL
- 31.6145 mL
- 63.2290 mL
- 5 mM
- 1.2646 mL
- 6.3229 mL
- 12.6458 mL
- 10 mM
- 0.6323 mL
- 3.1615 mL
- 6.3229 mL

技术信息

CAS号

62613-82-5

储存条件

粉末: Sealed in dry,Room Temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C6H10N2O3

运输

蓝冰

分子量

158.16

别名

ISF2522;CGP 21690E;Neuractiv;Hydroxypiracetam;奥拉西坦

溶解度

DMSO	30.0 mg/mL (189.7 mM)
Water	29.0 mg/mL (183.4 mM)
Ethanol	Insoluble

动物实验配方

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