|2-(4-苯甲酰苯氧基)-N-(1-苄基哌啶-4-基)乙酰胺|CsnPharm

CAS No.: 924416-43-3

阿迪普隆 Catalog No. CSN16061

Synonyms: SC-396658

AdipoRon is a selective agonist of AdipoR1 and AdipoR2 with Kd value of 1.8 μM and 3.1 μM, respectively, which can activate AMPK and PPARα signaling and ameliorates insulin resistance, dyslipidemia, and glucose intolerance in a model of type II diabetes and obesity.

规格	价格	促销价格	库存	数量

400-920-2911

sales@csnpharm.cn

tech@csnpharm.cn

加入购物车大规格询价

加入收藏

产品咨询

400-920-2911

sales@csnpharm.cn

tech@csnpharm.cn

纯度 & 质量文件批次:

靶点选择性

生物活性

实验方案

技术信息

生物活性

靶点 Adiponectin Receptor 1

Kd:1.8μM Adiponectin Receptor 2

Kd:3.1μM
描述Adiponectin is an antidiabetic adipokine secreted from adipocytes. AdipoR1 and AdipoR2 are the major adiponectin receptors (AdipoR) that activate the AMPK pathway and the PPAR-α pathway, respectively. AdipoRon is a small-molecule AdipoR agonist that binds to AdipoR1 and AdipoR2 with dissociation constant (K_d) values of 1.8 and 3.1μM, respectively, and R_max values of 14.6 and 8.6 resonance units, respectively. Treatment of C2C12 myotubes with 5-50μM AdipoRon led to an increase in AMPK phosphorylation in a dose-dependent manner. AdipoRon also dose-dependently increased PGC-1α expression and mitochondrial DNA content in C2C12 myotubes. Intravenous administration of AdipoRon at a dosage of 50mg/kg body weight significantly induced AMPK phosphorylation in the liver and skeletal muscles of wild-type mice but not Adipor1^-/- Adipor2^-/- double-knockout mice. In wild-type mice on a high-fat diet, oral administration of AdipoRon (50mg/kg body weight) for 10 days significantly reduced fasting plasma glucose and insulin levels as well as plasma concentrations of triglycerides and free fatty acid. AdipoRon treatment also increased the expression of genes related to mitochondrial biogenesis and fatty-acid oxidation in wild-type mice fed a high-fat diet. Oral administration of AdipoRon for 2 weeks significantly ameliorated insulin resistance, glucose intolerance, and dyslipidaemia in db/db mice fed a normal chow diet.^[3]
作用机制AdipoRon is a small-molecule AdipoR agonist that binds to both AdipoR1 and AdipoR2.^[3]
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT03032991	-	-	Recruiting	December 2020	Spain ... more >> Elvira Larqué Recruiting Murcia, Spain, 30100 Contact: Elvira Larqué, Dr 0034868884239 elvirada@um.es Contact: Cristina Campoy, MD 0034958240740 ccampoy@ugr.es Collapse <<

参考文献

[1] Wang Y, Wan Y, et al. Hepatoprotective effects of AdipoRon against d-galactosamine-induced liver injury in mice. Eur J Pharm Sci. 2016 Oct 10;93:123-31.
[2] Okada-Iwabu M, Yamauchi T, et al. A small-molecule AdipoR agonist for type 2 diabetes and short life in obesity. Nature. 2013 Nov 28;503(7477):493-9.
[3] Okada-Iwabu M, Yamauchi T, Iwabu M, et al. A small-molecule AdipoR agonist for type 2 diabetes and short life in obesity. Nature. 2013;503(7477):493-499. doi:10.1038/nature12656

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.3336 mL
- 11.6680 mL
- 23.3360 mL
- 5 mM
- 0.4667 mL
- 2.3336 mL
- 4.6672 mL
- 10 mM
- 0.2334 mL
- 1.1668 mL
- 2.3336 mL

技术信息

CAS号

924416-43-3

储存条件

粉末: Sealed in dry,Room Temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C27H28N2O3

运输

蓝冰

分子量

428.52

别名

SC-396658

溶解度

DMSO	85.0 mg/mL (198.4 mM)
Water	Insoluble
Ethanol	50.0 mg/mL (116.7 mM)

动物实验配方

大规格询价

号为必填项

姓名: 邮箱: 手机号:

留言:

提交

靶点	Description	IC50
Adiponectin Receptor 1		Kd:1.8μM
Adiponectin Receptor 2		Kd:3.1μM

阿迪普隆 Catalog No. CSN16061

靶点选择性

请登录您的专属账户

确认信息