生物活性

• 描述Fenofibric acid, an agonist of PPARα, is a lipid regulating agent available as delayed release capsules for oral administration.
• 临床研究

• NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
  NCT00359281	Healthy	Phase 2	Completed	-	United States, Pennsylvania ... more >> University of Pennsylvania Philadelphia, Pennsylvania, United States, 19104 Collapse <<
  NCT01356290	Medulloblastoma	Phase 2	Recruiting	April 2023	United States, Illinois ... more >> Ann & Robert H. Lurie Children's Hospital of Chicago Recruiting Chicago, Illinois, United States, 60611-2605 Contact: Emily Golbeck       egolbeck@luriechildrens.org    Contact: Kevin Ritt       kritt@luriechildrens.org    Principal Investigator: Stewart Goldman, MD          Sub-Investigator: Rishi Lulla, MD          United States, Massachusetts Dana-Farber Cancer Institute and Boston Children's Hospital Recruiting Boston, Massachusetts, United States, 02215 Contact: Joanne Kennedy, RN, BA    617-632-5324    Joanne_Kennedy1@dfci.harvard.edu    Principal Investigator: Susan Chi, MD          Austria Medical University of Graz Recruiting Graz, Austria, 8036 Contact: Elisabeth Hulla-Gumbsch    +43 316 385 ext 82686    elisabeth.hulla-gumbsch@klinikum-graz.at    Principal Investigator: Martin Benesch, MD          Medical University of Innsbruck Recruiting Innsbruck, Austria, 6020 Contact: Yvonne Ennemoser, MSc    +43 512 504 ext 23605    yvonne.ennemoser@tirol-kliniken.at    Principal Investigator: Roman Crazzolara, MD          Kepler Universitätsklinikum Med Campus IV Recruiting Linz, Austria, 4020 Contact: Martina Winkler    +43 5 7680 84 ext 24302    martina.winkler@gespag.at    Principal Investigator: Georg Ebetsberger, MD          Salzburger Universitätsklinikum Recruiting Salzburg, Austria, 5020 Contact: Agnes Gamper, MD    +43 662 448257 ext 759    a.gamper@salk.at    Principal Investigator: Agnes Gamper, MD          Medical University of Vienna Recruiting Vienna, Austria, 1090 Contact: Andreas Peyrl, MD    +43 1 40400 ext 32320    andreas.peyrl@meduniwien.ac.at    Contact: Irene Slavc, MD    +43 1 40400 ext 32320    irene.slavc@meduniwien.ac.at    Principal Investigator: Andreas Peyrl, MD          Sub-Investigator: Irene Slavc, MD          Czechia University Hospital Brno Recruiting Brno, Czechia, 61300 Contact: Alexandra Martincekova, MD    +420532234755    Martincekova.Alexandra@fnbrno.cz    Principal Investigator: Jaroslav Sterba, MD          Sub-Investigator: Zdenek Pavelka, MD          Motol University Hospital Prague Recruiting Prague, Czechia, 15006 Contact: Klara Hruba    +42 0224436401    klara.hruba@fnmotol.cz    Principal Investigator: David Sumerauer, MD          Denmark University hospital Rigshospitalet Recruiting Copenhagen, Denmark, 2100 Contact: Karsten Nysom, MD    +45 3545 0809    karsten.nysom@regionh.dk    Principal Investigator: Karsten Nysom, MD          France Centre Oscar Lambret Terminated Lille, France, 59037 Sweden Sahlgrenska Universitetssjukhuset Recruiting Göteborg, Sweden, 416 85 Contact: Karin Fritzson    +46 31 343 58 65    karin.fritzson@vgregion.se    Contact: Anna Schröder- Håkansson    +46 31 343 58 65    anna.schroder_hakansson@vgregion.se    Principal Investigator: Magnus Sabel, MD          Sub-Investigator: Birgitta Lannering, Prof          Universitetssjukhuset Linköping Recruiting Linköping, Sweden, 581 85 Contact: Birgitta Hellström    +46 10 103 13 54    birgitta.hellstrom@regionostergotland.se    Contact: Pernilla Augustsson    +46 10-103 13 50    pernilla.augustsson@regionostergotland.se    Principal Investigator: Irene Devenney, MD          Skånes universitetssjukhus Recruiting Lund, Sweden, 221 85 Contact: Yvonne Håkansson    +46 46-17 80 64    Yvonne.Hakansson@skane.se    Contact: Simon Johansson    +46 46-17 80 64    simon.johansson@skane.se    Principal Investigator: Helena Mörse, MD          Karolinska University Hospital Recruiting Stockholm, Sweden, SE-171 76 Contact: Carina Rinaldo    +46 8 517 701 51    carina.rinaldo@karolinska.se    Contact: Yvonne Copeland    +46 8 517 724 84    yvonne.copeland-wahlo@karolinska.se    Principal Investigator: Stefan Holm, MD          Norrlands Universitetssjukhus Recruiting Umeå, Sweden, 901 85 Contact: Marita Wikström-Larsson    +46 90-785 02 44    Marita.Vikstrom.Larsson@vll.se    Principal Investigator: Mattias Mattsson          Akademiska sjukhuset Recruiting Uppsala, Sweden, 751 85 Contact: Katarina Vallin    +46 18 611 34 94    katarina.vallin@akademiska.se    Principal Investigator: Anders Öberg, MD Collapse <<
  NCT00812955	Dyslipidemia, Hypercholesterol... more >>emia, Hypertriglyceridemia Collapse <<	Phase 3	Completed	-	-

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• 参考文献

• [1] Wang Z, Moran E, et al. PPARα regulates mobilization and homing of endothelial progenitor cells through the HIF-1α/SDF-1 pathway. Invest Ophthalmol Vis Sci. 2014 May 20;55(6):3820-32.

  [2] Arakawa R, Tamehiro N, et al. Fenofibric acid, an active form of fenofibrate, increases apolipoprotein A-I-mediated high-density lipoprotein biogenesis by enhancing transcription of ATP-binding cassette transporter A1 gene in a liver X receptor-dependent manner. Arterioscler Thromb Vasc Biol. 2005 Jun;25(6):1193-7.