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CAS No.: 144060-53-7
Synonyms: TEI 6720;TMX 67;FBX
Febuxostat is an inhibitor of xanthine oxidase with Ki of 0.6 nM and can affect the progression of renal disease.
生物活性
靶点 | Xanthine Oxidase Ki:0.6nM |
NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
---|---|---|---|---|---|
NCT03691688 | - | - | Recruiting | March 1, 2022 | China, Shanghai ... more >> Shanghai Zhongshan Hospital Recruiting Shanghai, Shanghai, China, 200032 Contact: Shalaimaiti Shali, MD 86+13761553110 shali@zs-hospital.sh.cn Contact: Yuxiang Dai, MD,PhD +86-13818988550 dai.yuxiang@zs-hospital.sh.cn Principal Investigator: Junbo Ge, Professor Collapse << |
NCT01361646 | Hyperuricemia ... more >> Gout Collapse << | Phase 1 | Completed | - | Korea, Republic of ... more >> Seoul National University Hospital Seoul, Korea, Republic of, 110-744 Collapse << |
NCT01508702 | Gout | Phase 3 | Completed | - | - |
实验方案
技术信息
CAS号 | 144060-53-7 | 储存条件 |
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分子式 | C16H16N2O3S | 运输 | 蓝冰 | |||||||
分子量 | 316.37 | 别名 | TEI 6720;TMX 67;FBX;Uloric;Adenuric;非布司他;非布索坦 | |||||||
溶解度 |
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动物实验配方 |
NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
---|
NCT03691688 | - | - | Recruiting | March 1, 2022 | China, Shanghai ... more >> Shanghai Zhongshan Hospital Recruiting Shanghai, Shanghai, China, 200032 Contact: Shalaimaiti Shali, MD 86+13761553110 shali@zs-hospital.sh.cn Contact: Yuxiang Dai, MD,PhD +86-13818988550 dai.yuxiang@zs-hospital.sh.cn Principal Investigator: Junbo Ge, Professor Collapse << |
NCT01361646 | Hyperuricemia ... more >> Gout Collapse << | Phase 1 | Completed | - | Korea, Republic of ... more >> Seoul National University Hospital Seoul, Korea, Republic of, 110-744 Collapse << |
NCT01508702 | Gout | Phase 3 | Completed | - | - |
NCT01712204 | Gout Flares | Phase 2 | Completed | - | Taiwan ... more >> Veterans General Hospital Taipei, Taiwan Collapse << |
NCT01712204 | - | - | Completed | - | - |
NCT02287818 | Gout | Phase 2 | Completed | - | Taiwan ... more >> Taipei Veteran General Hospital (TVGH) Taipei, Taiwan, 112 Collapse << |
NCT01563432 | Gout | Phase 1 | Completed | - | Korea, Republic of ... more >> Korea University Anam Hospital Seoul, Korea, Republic of Collapse << |
NCT03395977 | Oxidative Stress ... more >> Endothelial Function Cardiovascular System Hypertension Collapse << | Not Applicable | Recruiting | December 31, 2020 | Belgium ... more >> Erasme Hospital Recruiting Brussels, Belgique, Belgium, 1070 Contact: Benjamin De Becker +32474328542 Benjamin.De.Becker@erasme.ulb.ac.be Principal Investigator: Benjamin De Becker Collapse << |
NCT01508702 | - | - | Completed | - | - |
NCT02338128 | - | - | Unknown | January 2017 | China, Shanghai ... more >> Department of Nephrology & Rheumatology, Shanghai Tenth People's Hospital Shanghai, Shanghai, China, 200072 Collapse << |
NCT03336203 | Gout CKD Stag... more >>e 1-4 SUA Level (>8 mg/dL; 480 µmol/L) Collapse << | Phase 4 | Recruiting | March 1, 2021 | Ukraine ... more >> Medical Practice Prof D.Ivanov Recruiting Kiev, Ukraine, 01014 Contact: Dmytro Ivanov, MD, Prof 504448788 ivanovdd@i.kiev.ua Sub-Investigator: Tatyana B Bevzenko, MD, PhD Sub-Investigator: Oleg B Synyachenko, MD, PhD, Prof Sub-Investigator: Iryna Yu Golovach, MD, PhD, Prof Collapse << |
NCT00174967 | Gout | Phase 2 | Completed | - | - |
NCT00174941 | Gout | Phase 2 | Completed | - | - |
NCT00174941 | - | - | Completed | - | - |
NCT00174967 | - | - | Completed | - | - |
NCT03534037 | Hyperuricemia ... more >> Metabolic Syndrome Left Ventricular Diastolic Dysfunction Collapse << | Phase 4 | Active, not recruiting | March 2020 | Taiwan ... more >> Tri-service General Hospital, songshan branch Taipei, Songshan Dist., Taiwan, 105 Collapse << |
NCT01654276 | - | - | Completed | - | - |
NCT01510769 | Tophaceous Gout | Phase 3 | Completed | - | - |
NCT01654276 | Gout | Phase 4 | Completed | - | United States, Texas ... more >> UT Southwestern Medical Center Dallas, Texas, United States, 75390-8885 Collapse << |
NCT01510769 | - | - | Completed | - | - |
NCT02246673 | Gout | Phase 2 | Completed | - | United States, California ... more >> Anaheim, California, United States, 92801 Glendale, California, United States, 91206 United States, Florida South Miami, Florida, United States, 33143 United States, Kansas Overland Park, Kansas, United States, 66211 Overland Park, Kansas, United States, 66212 United States, Texas Dallas, Texas, United States, 75231 Collapse << |
NCT02060552 | Primary Gout | Phase 4 | Completed | - | China, Hubei ... more >> Yikai YU Wuhan, Hubei, China, 430030 Collapse << |
NCT02317861 | Gout and Asymptomatic Hyperuri... more >>cemia Collapse << | Phase 1 Phase 2 | Completed | - | Japan ... more >> Research Site Fukuoka-shi, Japan Collapse << |
NCT01808144 | Gout | Phase 3 | Completed | - | - |
NCT01112982 | Gout | Phase 4 | Completed | - | United States, Florida ... more >> University of South Florida Medical Clinics Tampa, Florida, United States, 33612-4742 Collapse << |
NCT01808144 | - | - | Completed | - | - |
NCT02252835 | Gout Hyperuri... more >>cemia Collapse << | Phase 2 | Completed | - | United States, Kansas ... more >> Vince & Associates Clinical Research Overland Park, Kansas, United States, 66212 Collapse << |
NCT03200210 | Hyperuricemia | Phase 4 | Recruiting | July 2022 | China, Guangdong ... more >> The First Affiliated Hospital of Sun Yat-sen University Recruiting Guangzhou, Guangdong, China, 510000 Contact: Xueqing Yu, M.D. & Ph.D 8620-8776633 yuxq@mail.sysu.edu.cn Contact: Yu Principal Investigator: Xueqing Yu, M.D. & Ph.D. Collapse << |
NCT00821392 | Gout | Phase 3 | Completed | - | - |
NCT02246673 | - | - | Completed | - | - |
NCT00175019 | Gout | Phase 3 | Completed | - | - |
NCT01416402 | Hyperuricemia ... more >> Gout Collapse << | Phase 2 | Completed | - | United States, Kansas ... more >> Overland Park, Kansas, United States, 66212 Collapse << |
NCT00175019 | - | - | Completed | - | - |
NCT00430248 | Gout | Phase 3 | Completed | - | - |
NCT00174915 | - | - | Completed | - | - |
NCT00102440 | Gout | Phase 3 | Completed | - | - |
NCT00430248 | - | - | Completed | - | - |
NCT02128490 | - | - | Completed | - | - |
NCT03425708 | Hyperuricemia ... more >> Chronic Renal Disease Collapse << | Phase 4 | Recruiting | December 31, 2018 | China, Jiangsu ... more >> The Affiliated Hospital of Xuzhou Medical University Recruiting Xuzhou, Jiangsu, China, 221000 Contact: Dong Sun, MD 15862158578 sundong126@yahoo.com Collapse << |
NCT02139046 | Gout | Phase 3 | Completed | - | - |
NCT00102440 | - | - | Completed | - | - |
NCT02500641 | Gout | Phase 4 | Completed | - | Germany ... more >> Dresden, Germany Italy Avezzano, Italy Bologna, Italy Brescia, Italy Chieti, Italy Coppito, Italy Netherlands Reade Amsterdam, Netherlands Poland Gdansk, Poland Grudziadz, Poland Katowice, Poland Krakow, Poland Lodz, Poland Warsaw, Poland Zgierz, Poland Romania Bucharest, Romania Craiova, Romania Timisoara, Romania Serbia Belgrade, Serbia Collapse << |
NCT00174915 | Gout | Phase 3 | Completed | - | - |
NCT01328769 | Hypertension | Phase 4 | Completed | - | United States, Utah ... more >> Cardiovascular Genetics, University of Utah Salt Lake City, Utah, United States, 84108 Collapse << |
NCT02139046 | - | - | Completed | - | - |
NCT01077284 | Hyperuricosuria ... more >> Kidney Stones Collapse << | Phase 2 | Completed | - | - |
NCT01328769 | - | - | Completed | - | - |
NCT01077284 | - | - | Completed | - | - |
NCT01736514 | Gout | Phase 3 | Completed | - | Taiwan ... more >> Kaohsiung, Taiwan Linkou, Taiwan Taichung, Taiwan Taipei, Taiwan Collapse << |
NCT02866214 | Endothelial Dysfunction ... more >> Endstage Renal Disease Collapse << | Phase 2 Phase 3 | Completed | - | - |
NCT02082769 | Gout | Phase 3 | Completed | - | - |
NCT02128490 | Gout Moderate... more >> Renal Impairment Collapse << | Phase 2 | Completed | - | - |
NCT02082769 | - | - | Completed | - | - |
NCT03605212 | Tumor Lysis Syndrome | Phase 1 Phase 2 | Recruiting | July 2019 | Bulgaria ... more >> University Hospital Tsaritsa Yoanna Not yet recruiting Sofia, Bulgaria, 1527 Hungary Semmelweis Egyetem (paediatric) Not yet recruiting Budapest, Hungary, 1083 Semmelweis Egyetem Recruiting Budapest, Hungary, 1085 Debreceni Egyetem Klinikai Központ Terminated Debrecen, Hungary, 4032 Italy SOC Oncologia Medica A - Centro di Riferimento Oncologico Recruiting Aviano, Pordenone, Italy, 33081 Policlinico S. Orsola Malpighi Recruiting Bologna, Italy, 40138 A.O.U.C. Azienda Ospedaliero - Universitaria Careggi Not yet recruiting Firenze, Italy, 50134 Azienda Ospedaliero Universitaria Meyer Not yet recruiting Firenze, Italy, 50139 Istituto G Gaslini Ospedale Pediatrico IRCCS Not yet recruiting Genova, Italy, 16147 Azienda Ospedaliero-Universitaria Pisana Terminated Pisa, Italy, 56126 IRCCS Ospedale Pediatrico Bambino Gesù Not yet recruiting Rome, Italy, 00165 Ospedale Infantile Regina Margherita Recruiting Torino, Italy, 10126 Azienda Ospedaliera Universitaria Integrata di Verona Not yet recruiting Verona, Italy, 37126 Spain Hospital de San Pedro de Alcantara Recruiting Caceres, Spain, 10002 Hospital General Universitario Gregorio Maranon Recruiting Madrid, Spain, 28007 Hospital Universitario La Paz Not yet recruiting Madrid, Spain, 28046 Hospital Universitari i Politècnic La Fe Recruiting Valencia, Spain, 46026 Collapse << |
NCT02382640 | - | - | Completed | - | - |
NCT02382640 | Healthy Volunteers | Phase 1 | Completed | - | United States, Texas ... more >> Austin, Texas, United States, 78744 Collapse << |
NCT03372200 | Hyperuricemia With or Without ... more >>Gout Collapse << | Phase 3 | Completed | - | Japan ... more >> Mochida Investigational sites Tokyo, Japan Collapse << |
NCT02338323 | Chronic Kidney Disease ... more >> Hyperuricemia Abnormal Renal Function Collapse << | Not Applicable | Unknown | December 2018 | China, Shanghai ... more >> Department of Nephrology & Rheumatology, Shanghai Tenth People's Hospital Recruiting Shanghai, Shanghai, China, 200072 Contact: Ai Peng, MD, PhD pengai@tongji.edu.cn Contact: Ling Wang, MD, PhD nowax@126.com Sub-Investigator: Ling Wang, MD, PhD Collapse << |
NCT02944214 | Chronic Kidney Disease ... more >> Hyperuricemia Abnormal Renal Function Collapse << | Not Applicable | Not yet recruiting | December 2019 | China, Shanghai ... more >> Department of Nephrology & Rheumatology, Shanghai Tenth People's Hospital Not yet recruiting Shanghai, Shanghai, China, 200072 Contact: Ai Peng, MD, PhD pengai@tongji.edu.cn Collapse << |
NCT01472692 | Prehypertension ... more >> Gout Pulse Wave Velocity Hypertension 24 Hour Blood Pressure Collapse << | Phase 4 | Completed | - | United States, California ... more >> Univerisity Of California San Diego San Diego, California, United States, 92037 Collapse << |
NCT02752633 | Adenine Phosphoribosyltransfer... more >>ase Deficiency Collapse << | Phase 4 | Completed | - | Iceland ... more >> Landspitali - The National University Hospital of Iceland Reykjavik, Iceland, 101 Collapse << |
NCT01101035 | - | - | Completed | - | - |
NCT01101035 | Cardiovascular Disease | Phase 3 | Completed | - | - |
NCT02752633 | - | - | Completed | - | - |
NCT03767322 | Contrast-induced Nephropathy ... more >> Contrast-induced Acute Kidney Injury Collapse << | Phase 2 | Not yet recruiting | December 2019 | Mexico ... more >> Instituto Nacional de Cardiologia Ignacio Chavez Not yet recruiting Mexico City, México City, Mexico Contact: Magdalena Madero, MD 015255 5573 2911 ext 21425 madero.magdalena@gmail.com Contact: Salvador Lopez-Gil, MD 015255 5573 2911 ext 21425 salvadorlgil@gmail.com Collapse << |
NCT01724528 | - | - | Completed | - | - |
NCT02344602 | Type 1 Diabetes Mellitus | Phase 4 | Completed | - | Canada, Ontario ... more >> Renal Physiology Laboratory, University Health Network Toronto, Ontario, Canada, M5G 2N2 Collapse << |
NCT01724528 | Tumor Lysis Syndrome | Phase 3 | Completed | - | - |
NCT00995618 | Gout Hyperuri... more >>cemia Collapse << | Phase 2 | Completed | - | United States, Hawaii ... more >> Nuon Investigative Site Honolulu, Hawaii, United States United States, Indiana Nuon Investigative Site Evansville, Indiana, United States United States, Texas Nuon Investigative Site Dallas, Texas, United States Collapse << |
NCT01082640 | Renal Impairment | Phase 2 | Completed | - | - |
NCT01082640 | - | - | Completed | - | - |
NCT02504320 | - | - | Completed | - | - |
NCT03131583 | Gout | Phase 1 | Recruiting | June 2017 | China, Jiangsu ... more >> The First Affiliated Hospital of Soochow University Recruiting Suzhou, Jiangsu, China, 215006 Contact: Liyan Miao 18915505252 miaolysuzhou@163.com Collapse << |
NCT01078389 | Joint Damage | Phase 2 | Completed | - | - |
NCT01078389 | - | - | Completed | - | - |
NCT01496469 | Hypertension | Phase 2 | Completed | - | - |
NCT02504320 | Healthy Volunteers | Phase 1 | Completed | - | United States, Texas ... more >> Austin, Texas, United States, 78744 Collapse << |
NCT01496469 | - | - | Completed | - | - |
NCT02279342 | Coronary Artery Disease | Phase 4 | Terminated(Entry were insuffic... more >>ient as expected.) Collapse << | - | Japan ... more >> Yokohama City University Medical Center Yokohama, Kanagawa, Japan, 232-0024 Collapse << |
NCT01984749 | Hyperuricemia | Not Applicable | Unknown | - | - |
NCT03149939 | Hyperuricemia ... more >> Hemodialysis Complication Collapse << | Not Applicable | Completed | - | - |
NCT01350388 | Chronic Kidney Disease ... more >> Diabetes Collapse << | Not Applicable | Completed | - | United States, Utah ... more >> University of Utah Salt Lake City, Utah, United States, 84112 Collapse << |
NCT01350388 | - | - | Completed | - | - |
NCT02374164 | Gout | Phase 1 | Completed | - | United States, Texas ... more >> Austin, Texas, United States Collapse << |
NCT01549977 | - | - | Terminated(Business Decision (... more >>please see below)) Collapse << | - | - |
NCT02579096 | Gout Chronic ... more >>Kidney Diseases Collapse << | Phase 4 | Recruiting | September 30, 2021 | - |
NCT02374164 | - | - | Completed | - | - |
NCT03316131 | Asymptomatic Hyperuricemia | Phase 2 | Completed | - | United States, California ... more >> Research Site Glendale, California, United States, 91206 United States, Maryland Research Site Baltimore, Maryland, United States, 21225 Collapse << |
NCT01883167 | Healthy | Phase 1 | Completed | - | United States, Michigan ... more >> Kalamazoo, Michigan, United States, 49007 Collapse << |
NCT03118739 | Hyperuricemia ... more >> Albuminuria Type 2 Diabetes Collapse << | Phase 2 | Completed | - | United States, California ... more >> Research Site Canyon Country, California, United States, 91351 Research Site Chula Vista, California, United States, 91911 Research Site Corona, California, United States, 92882 Research Site Escondido, California, United States, 92025 Research Site Lakewood, California, United States, 90805 Research Site Lincoln, California, United States, 95648 Research Site Los Angeles, California, United States, 90017 Research Site Los Angeles, California, United States, 90022 Research Site Los Angeles, California, United States, 90036 Research Site North Hollywood, California, United States, 91606 Research Site Oceanside, California, United States, 92056-4510 Research Site Orange, California, United States, 92868 Research Site Sacramento, California, United States, 95821 United States, Texas Research Site Houston, Texas, United States, 77058 Research Site Houston, Texas, United States, 77070 Research Site Pearland, Texas, United States, 77584 Research Site Sugar Land, Texas, United States, 77478 Research Site Webster, Texas, United States, 77598 Collapse << |
NCT01763996 | - | - | Completed | - | - |
NCT01549977 | Angina | Phase 2 | Terminated(Business Decision (... more >>please see below)) Collapse << | - | United States, California ... more >> Carmichael, California, United States Fresno, California, United States Irvine, California, United States Paramount, California, United States Sacramento, California, United States San Diego, California, United States United States, Florida Tampa, Florida, United States United States, Georgia Dunwoody, Georgia, United States Suwanee, Georgia, United States United States, Kentucky Lexington, Kentucky, United States United States, Missouri St. Louis, Missouri, United States St. Peters, Missouri, United States United States, North Carolina Salisbury, North Carolina, United States United States, Ohio Columbus, Ohio, United States Lyndhurst, Ohio, United States United States, Oklahoma Oklahoma City, Oklahoma, United States United States, Pennsylvania Tipton, Pennsylvania, United States United States, Texas San Antonio, Texas, United States United States, Virginia Manassas, Virginia, United States United States, Washington Port Orchard, Washington, United States United States, Wisconsin Madison, Wisconsin, United States Collapse << |
NCT01701622 | - | - | Terminated(unable to enroll pa... more >>rticipants) Collapse << | - | - |
NCT02600780 | Hyperuricemia | Phase 4 | Completed | - | Pakistan ... more >> Dow University of Health Sciences Karachi, Sindh, Pakistan, 74900 Collapse << |
NCT01763996 | Coronary Artery Disease | Phase 4 | Completed | - | United States, Maryland ... more >> Baltimore, Maryland, United States Collapse << |
NCT01701622 | Blood Pressure ... more >> Gout Collapse << | Not Applicable | Terminated(unable to enroll pa... more >>rticipants) Collapse << | - | United States, Mississippi ... more >> University of Mississippi Medical Center General Medicine/Hypertension and Family Medicine Clinics Jackson, Mississippi, United States, 39216 Collapse << |
靶点 | Description | IC50 |
---|---|---|
Xanthine Oxidase | Ki:0.6nM |
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