|2-((6-苯基-2,3,4,9-四氢-1H-咔唑-1-基)氨基)乙醇|CsnPharm

CAS No.: 425399-05-9

2-((6-Phenyl-2,3,4,9-tetrahydro-1H-carbazol-1-yl)amino)ethan-1-ol Catalog No. CSN16977

Synonyms: Pirl1-related Compound 2

CASIN is an inhibitor of GTPase Cdc42 with IC50 of 2 μM that can generat a rejuvenated phenotype of HSCs.

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技术信息

生物活性

描述Elevated activity of the small RhoGTPase Cdc42 in aged HSCs (hematopoietic stem cells) is causally linked to HSC aging and correlates with a loss of polarity in aged HSCs. Pharmacological inhibition of Cdc42 activity functionally rejuvenates aged HSCs. CASIN is a selective Cdc42 activity inhibitor. In young cells, treatment with CASIN (5 µM) reduced the elevated level of active Cdc42 observed in aged primitive hematopoietic cells to the level observed in young cells. In response to treatment with 5 µM CASIN, LT-HSCs from aged mice showed a dose-dependent increase in the percentage of polarized cells, becoming progressively indistinguishable from young cells. These data indicated that CASIN treatment reverted aged LT-HSCs to young HSCs with respect to the polarity phenotype. Surprisingly, the increase in the percentage of polar cells among aged LT-HSCs induced by CASIN in vitro remained stable for at least up to 6 hours after CASIN withdrawal. Further, CASIN treatment of aged LT-HSCs resulted in an increase in contribution to the B-cell compartment in PB (peripheral blood) and a reduced contribution to the myeloid lineage. In addition, CASIN treatment increased the contribution to LSK and common lymphoid progenitor (CLP) populations to a level indistinguishable from young LT-HSCs. CASIN treatment induces a sharp decrease of the frequency of AcH4K16^low aged LT-HSCs while increasing the frequency of AcH4K16^high cells^[3].
参考文献

[1] Cao C, Guo S, et al. Luminescent properties of NaGdF4: Ln3+ (Ln3+ = Ce3+, Tb3+) phosphors. J Nanosci Nanotechnol. 2014 May;14(5):3735-8.
[2] Gal ZA, Mallinson PM, et al. Synthesis and structure of alkaline earth silicon nitrides: BaSiN(2), SrSiN(2), and CaSiN(2). Inorg Chem. 2004 Jun 28;43(13):3998-4006.
[3] Florian MC, Dörr K, Niebel A, et al. Cdc42 activity regulates hematopoietic stem cell aging and rejuvenation. Cell Stem Cell. 2012;10(5):520-530.

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 3.2637 mL
- 16.3185 mL
- 32.6369 mL
- 5 mM
- 0.6527 mL
- 3.2637 mL
- 6.5274 mL
- 10 mM
- 0.3264 mL
- 1.6318 mL
- 3.2637 mL

技术信息

CAS号

425399-05-9

储存条件

粉末: Sealed in dry,Store in freezer, under -20°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C20H22N2O

运输

蓝冰

分子量

306.40

别名

Pirl1-related Compound 2

溶解度

DMSO	140.0 mg/mL (456.9 mM)
Water	insoluble

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2-((6-Phenyl-2,3,4,9-tetrahydro-1H-carbazol-1-yl)amino)ethan-1-ol Catalog No. CSN16977

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