|2-[[4-[(7-氯喹啉-4-基)氨基]戊基](乙基)氨基]乙醇|CsnPharm

CAS No.: 118-42-3

羟氯喹 Catalog No. CSN25649

Synonyms: Hydrochloroquine;Ercoquin;Plaquinol

Hydroxychloroquine is an antimalarial agent used for the treatment of systemic lupus erythematosus, rheumatoid arthritis and other autoimmune, inflammatory and dermatologic conditions. Also acts as an inhibitor of autophagy and toll-like receptor (TLR)7/9.

规格	价格	促销价格	库存	数量

400-920-2911

sales@csnpharm.cn

tech@csnpharm.cn

加入购物车大规格询价

加入收藏

产品咨询

400-920-2911

sales@csnpharm.cn

tech@csnpharm.cn

纯度 & 质量文件批次:

靶点选择性

生物活性

实验方案

技术信息

生物活性

描述Hydroxychloroquine (HCQ) is an alkalinizing lysosomatropic drug that accumulates in lysosomes where it inhibits some important functions by increasing the pH. HCQ may reduce the risk of flares, allow the reduction of the dosage of steroids, reduce organ damage, and prevent the thrombotic effects of anti-phospholipid antibodies^[1].Hydroxychloroquine and its predecessor chloroquine are medications commonly used in the treatment of systemic lupus erythematosus, rheumatoid arthritis, and other connective tissue disorders. Hydroxychloroquine interferes with malarial metabolites, confers immunomodulatory effects, and also affects lysosomal function. Retinal toxicity, neuromyopathy, and cardiac disease are recognized adverse effects of hydroxychloroquine^[2]. Moreover, the impact of HCQ on cytokine production and suppression of antigen presentation may have immunologic consequences that hamper innate and adaptive antiviral immune responses for patients with COVID-19^[3].
参考文献

[1] Ponticelli C, Moroni G. Hydroxychloroquine in systemic lupus erythematosus (SLE). Expert Opin Drug Saf. 2017 Mar;16(3):411-419
[2] Yogasundaram H, Putko BN, Tien J, Paterson DI, Cujec B, Ringrose J, Oudit GY. Hydroxychloroquine-induced cardiomyopathy: case report, pathophysiology, diagnosis, and treatment. Can J Cardiol. 2014 Dec;30(12):1706-15
[3] Meyerowitz EA, Vannier AGL, Friesen MGN, Schoenfeld S, Gelfand JA, Callahan MV, Kim AY, Reeves PM, Poznansky MC. Rethinking the role of hydroxychloroquine in the treatment of COVID-19. FASEB J. 2020 May;34(5):6027-6037

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.9773 mL
- 14.8866 mL
- 29.7733 mL
- 5 mM
- 0.5955 mL
- 2.9773 mL
- 5.9547 mL
- 10 mM
- 0.2977 mL
- 1.4887 mL
- 2.9773 mL

技术信息

CAS号	118-42-3	储存条件	粉末 Keep in dark place,Sealed in dry,Room Temperature 液体 -20°C:3-6 月 -80°C:12月
分子式	C18H26ClN3O	运输	蓝冰
分子量	335.87	别名	Hydrochloroquine;Ercoquin;Plaquinol;Toremonil;Oxychlorochin;Oxychloroquine;Plaquenil;WIN 1258;Z0188;羟氯喹;羟基氯喹

大规格询价

号为必填项

姓名: 邮箱: 手机号:

留言:

提交

羟氯喹 Catalog No. CSN25649

靶点选择性

请登录您的专属账户

确认信息