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CAS No.: 4394-00-7

氟尼酸 Catalog No. CSN12665

Synonyms: Niflumic Acid;Actol;Donalgin

Niflumic acid, a Ca2+-activated Cl- channel blocker, is an analgesic and anti-inflammatory agent used in the treatment of rheumatoid arthritis.

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技术信息

生物活性

描述Niflumic acid, a drug used for joint and muscular pain, affected Ca²⁺ signaling in different models. In MG63 cells, niflumic acid induced [Ca²⁺]i rises by evoking PLC-dependent (phospholipase C) Ca²⁺ release from the endoplasmic reticulum, and Ca²⁺ entry via PKC-sensitive (protein kinase C) store-operated Ca²⁺ entry. Niflumic acid also induced Ca²⁺-independent cell death^[3]. Niflumic acid (10 and 30 mM) also inhibited the noradrenaline-induced increase in perfusion pressure and 30 mM niflumic acid reduced the pressor response to 1 nmol noradrenaline by 34 +/- 6%. The increases in perfusion elicited by 5-HT (0.3 and 3 nmol) were reduced by niflumic acid (10 and 30 mM) in a concentration-dependent manner and 30 mM niflumic acid inhibited responses to 0.3 and 3 nmol 5-HT by, respectively, 49 +/- 8% and 50 +/- 7%. Niflumic acid selectively reduces a component of noradrenaline- and 5-HT-induced pressor responses by inhibiting a mechanism which leads to the opening of voltage-gated calcium channels^[4]. Niflumic acid restored core and associated symptoms of peripheral neuropathy by suppressing oxidative-nitrosative stress, inflammatory cytokines (TNF-α, IL-1β) and TRPV1 level in stavudine-induced neuropathic pain in rats. Pharmacological efficacy of niflumic acid (20 mg/kg) was equivalent to pregabalin (30 mg/kg) ^[5].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 3.5434 mL
- 17.7168 mL
- 35.4336 mL
- 5 mM
- 0.7087 mL
- 3.5434 mL
- 7.0867 mL
- 10 mM
- 0.3543 mL
- 1.7717 mL
- 3.5434 mL

技术信息

CAS号

4394-00-7

储存条件

粉末: Keep in dark place,Inert atmosphere,Room temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C13H9F3N2O2

运输

蓝冰

分子量

282.22

别名

Niflumic Acid;Actol;Donalgin;Nifluril;UP83;Landruma;Flunir;Niflactol;Niflugel;氟尼酸

溶解度

DMSO	55.0 mg/mL (194.9 mM)
Water	Insoluble
Ethanol	Insoluble

动物实验配方

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