|3-(2-吡啶基二硫基)丙酸 N-羟基琥珀酰亚胺酯|CsnPharm

CAS No.: 68181-17-9

Synonyms: SPDP Crosslinker

SPDP is used for antibody conjugation and as a protein cross-linker.

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400-920-2911

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生物活性

描述SPDP (SPDP Crosslinker) is a short-chain crosslinker for amine-to-sulfhydryl conjugation via NHS-ester and pyridyldithiol reactive groups that form cleavable (reducible) disulfide bonds with cysteine sulfhydryls. It is a glutathione cleavable ADC linker used for the antibody-drug conjugates (ADCs)^[2]. DAC micelles were chemically linked onto the PAA-BP-modified stents by using N-succinimidyl-3-(2-pyridyldithiol)-propionate (SPDP) as a crosslinker^[3]. The Vi (capsular polysaccharide) was bound to the porins by a heterobifunctional cross-linking reagent, N-succinimidyl-3-(2-pyridyl dithio)-propionate (SPDP)^[4]. Based on the results obtained from morphological characterization, in vitro release, and therapeutic efficacy in cells, N-succinimidyl 3-(2-pyridyldithio) propionate (SPDP)-modified ABNs (ABN-SPDP) was chosen. Since ABN-SPDP are formed with disulfide linkage, the drug release is facilitated under a highly reducing environment present in the tumor sites^[5].
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT01166048	Chronic Low Back Pain	Phase 4	Completed	-	Austria ... more >> Department of Special Anesthesia and Pain Therapy, Medical University of Vienna, AKH Vienna Vienna, Austria, 1090 Collapse <<
NCT02968433	Parkinson Disease(PD)	Phase 1	Active, not recruiting	December 2018	United States, California ... more >> Stanford Movement Disorders Clinic Stanford, California, United States, 94304 Collapse <<

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技术信息

CAS号	68181-17-9	储存条件	粉末 Keep in dark place,Inert atmosphere,Store in freezer, under -20°C 液体 -20°C:3-6 月 -80°C:12月
分子式	C12H12N2O4S2	运输	蓝冰
分子量	312.36	别名	SPDP Crosslinker

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