|2.5-二羟基苯甲酸|CsnPharm

CAS No.: 490-79-9

龙胆酸 Catalog No. CSN17019

Synonyms: 2,5-二羟基苯甲酸;龙胆酸

Gentisic acid is a natural product isolated and purified from the roots of Gentiana scabra Bunge.

规格	价格	促销价格	库存	数量

400-920-2911

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技术信息

生物活性

描述Gentisic acid (GA), a natural compound, widely exists in many plants and have many biological activities, such as antioxidant, anti-inflammatory and antibiotic activities^[1] . In vitro studies, it was found that gentisic acid had no cytotoxicity, but had antimutagenic activity at special concentration on HTC cells^[1] . Besides this, gentisic acid could also protect rat liver mitochondria (RLM) and human erythrocytes against the oxidation and radiation^[2] . In vivo studies, it was observed that gentisic acid had the ability of improving the cardiac hypertrophy and fibrosis in mice through inhibiting ERK1/2 pathway, when given 100 mg/kg/d for 3 weeks^[3] .
参考文献

[1] Cavalcante FML, Almeida IV, et al. Cytotoxicity, mutagenicity, and antimutagenicity of the gentisic acid on HTC cells. Drug Chem Toxicol. 2017 May 16:1-7.
[2] Joshi R, Gangabhagirathi R, et al. Antioxidant activity and free radical scavenging reactions of gentisic acid: in-vitro and pulse radiolysis studies. Free Radic Res. 2012;46(1):11-20.
[3] Sun S, Kee HJ, et al. Gentisic acid attenuates pressure overload-induced cardiac hypertrophy and fibrosis in mice through inhibition of the ERK1/2 pathway. J Cell Mol Med. 2018;22(12):5964-5977.

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 6.4885 mL
- 32.4423 mL
- 64.8845 mL
- 5 mM
- 1.2977 mL
- 6.4885 mL
- 12.9769 mL
- 10 mM
- 0.6488 mL
- 3.2442 mL
- 6.4885 mL

技术信息

CAS号

490-79-9

储存条件

粉末: Sealed in dry,Room Temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C7H6O4

运输

蓝冰

分子量

154.12

别名

2,5-二羟基苯甲酸;龙胆酸

溶解度

DMSO	29.0 mg/mL (188.2 mM)
Ethanol	30.0 mg/mL (194.7 mM)

动物实验配方

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