|2,5-二氨基-2-(二氟甲基)五烯酸盐酸盐水合物|CsnPharm

CAS No.: 96020-91-6

依氟鸟氨酸盐酸盐一水合物 Catalog No. CSN12752

Synonyms: DFMO hydrochloride hydrate;MDL-71782 hydrochloride hydrate;RMI-71782 hydrochloride hydrate

Eflornithine HCl is a specific, irreversible inhibitor of the enzyme ornithine decarboxylase, is a medication for the treatment of African trypanosomiasis and excessive facial hair growth in women.

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技术信息

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描述Eflornithine hydrochloride hydrate is a specific, irreversible inhibitor of the enzyme ornithine decarboxylase. In subjects with excessive, unwanted facial hair, eflornithine 15% cream is superior to placebo in reducing hair growth. After 24 weeks' treatment, 58% of eflornithine and 34% of placebo subjects have at least some improvement in facial hirsutism^[3]. The hair growth inhibitory activity of eflornithine was significantly enhanced when the eflornithine cream was applied onto a mouse skin area pretreated with microneedles. Cell proliferation in the skin and hair follicles was also significantly inhibited when the eflornithine cream was applied onto a skin area pretreated with microneedles^[4]. Treatment of coarctation hypertensive rats with eflornithine resulted in a normalization of the contractile intensity to KCI and norepinephrine and relaxations to acetylcholine by 14 days of hypertension. Normalization of vascular function can occur in the presence of significantly elevated blood pressure upon chronic administration of eflornithine^[5]. Male SD rats were administered single doses of racemic eflornithine hydrochloride as an oral solution (750, 1,500, 2,000, or 3,000 mg/kg of body weight) or intravenously (375 or 1,000 mg/kg of body weight). The mean bioavailabilities for L- and D-eflornithine were 41% and 62%, respectively, in the dose range of 750 to 2,000 mg/kg of body weight, with suggested increases to 47% and 83%, respectively, after a dose of 3,000 mg/kg of body weight^[6].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 4.2257 mL
- 21.1287 mL
- 42.2574 mL
- 5 mM
- 0.8451 mL
- 4.2257 mL
- 8.4515 mL
- 10 mM
- 0.4226 mL
- 2.1129 mL
- 4.2257 mL

技术信息

CAS号

96020-91-6

储存条件

粉末: Inert atmosphere,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C6H15ClF2N2O3

运输

蓝冰

分子量

236.64

别名

DFMO hydrochloride hydrate;MDL-71782 hydrochloride hydrate;RMI-71782 hydrochloride hydrate;α-difluoromethylornithine hydrochloride hydrate;Difluoromethylornithine HCl Hydrate;DFMO HCl Hydrate;MDL 71782 HCl Hydrate;RMI-71782 HCl Hydrate;DL-α-Difluoromethylornithine (hydrochloride hydrate);DFMO;Eflornithine;Eflornithine HCl hydrate;Eflornithine HCl;Eflornithine hydrochloride;Ornidyl.CPP-1X;RMI-71782;DL-Ornithine hydrochloride

溶解度

DMSO	Insoluble
Water	45.0 mg/mL (190.2 mM)
Ethanol	Insoluble

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依氟鸟氨酸盐酸盐 一水合物 Catalog No. CSN12752

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依氟鸟氨酸盐酸盐一水合物 Catalog No. CSN12752