|2,5-二叔丁基对苯二酚|CsnPharm

CAS No.: 88-58-4

2,5-Di-tert-butylhydroquinone/2,5-二叔丁基对苯二酚 Catalog No. CSN23530

Synonyms: 2;5-di-t-butyl-1;4-benzohydroquinone

BHQ is a selective inhibitor of sarco-endoplasmic reticulum Ca2+-ATPase (SERCA).

规格	价格	促销价格	库存	数量

400-920-2911

sales@csnpharm.cn

tech@csnpharm.cn

加入购物车大规格询价

加入收藏

产品咨询

400-920-2911

sales@csnpharm.cn

tech@csnpharm.cn

纯度 & 质量文件批次:

靶点选择性

生物活性

实验方案

技术信息

生物活性

描述The importance of the Ca²⁺-ATPases of the surface and endoplasmic reticulum membranes in regulating the intracellular Ca²⁺ concentrations in living cells has been recognized as a result of the development of biophysical techniques and finding of useful pharmacological tool drugs^[1]. BHQ is a potent and selective inhibitor of the sarco-endoplasmic reticulum Ca²⁺-ATPase (SERCA). In rat tail artery myocytes, BHQ reduced I_Ca(L) in a concentration- and voltage-dependent manner with an IC₅₀ of 66.7 μM^[2]. In rat basophilic leukaemia (RBL-2H3) cells under whole cell voltage clamp, a maximal blockade of inward current was obtained within 6 min after perfusion with 10 μM BHQ which caused depolarization of the cell which would affect Ca²⁺ influx^[3].
参考文献

[1] Furukawa KI. Ca²⁺-ATPase. Nihon Rinsho. 1996 Mar;54(3):601-6
[2] Fusi F, et al. 2,5-Di-t-butyl-1,4-benzohydroquinone (BHQ) inhibits vascular L-type Ca²⁺ channel via superoxide anion generation. Br J Pharmacol. 2001 Aug;133(7):988-96
[3] Hasséssian H, et al. Blockade of the inward rectifier potassium current by the Ca²⁺-ATPase inhibitor 2',5'-di(tert-butyl)-1,4-benzohydroquinone (BHQ). Br J Pharmacol. 1994 Aug;112(4):1118-22

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 4.4980 mL
- 22.4901 mL
- 44.9802 mL
- 5 mM
- 0.8996 mL
- 4.4980 mL
- 8.9960 mL
- 10 mM
- 0.4498 mL
- 2.2490 mL
- 4.4980 mL

技术信息

CAS号

88-58-4

储存条件

粉末: Keep in dark place,Inert atmosphere,Room temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C14H22O2

运输

蓝冰

分子量

222.32

别名

2;5-di-t-butyl-1;4-benzohydroquinone;dt-BHQ

溶解度

DMSO	10.0 mg/mL (45.0 mM)
Water	Insoluble
Ethanol	40.0 mg/mL (179.9 mM)

动物实验配方

大规格询价

号为必填项

姓名: 邮箱: 手机号:

留言:

提交

2,5-Di-tert-butylhydroquinone/2,5-二叔丁基对苯二酚 Catalog No. CSN23530

靶点选择性

请登录您的专属账户

确认信息