|2,4,5-三甲氧基苯甲醛|CsnPharm

CAS No.: 4460-86-0

细辛醛 Catalog No. CSN16343

Synonyms: 细辛醛;Asaronaldehyde;2,4,5-trimethoxy-Benzaldehyde

Asaronaldehyde is a COX-2 inhibitor, exhibiting 17-fold selectivity over COX-1, it's a natural product isolated and purified from the rhizoma of Acorus tatarinowii Schott.

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实验方案

技术信息

生物活性

描述Asarylaldehyde (2,4,5-TMBA) is a natural COX-2 inhibitor, which isolated from carrot (Daucus carota L.) seeds significantly inhibits cyclooxygenase II (COX-2) activity at the concentration of 100 μg/mL compared to three commercial nonsteroidal anti-inflammatory drugs Aspinin, Ibuprofen, and Naproxen at their IC50 values 180, 2.52, and 2.06 μg/mL, respectively. 2,4,5-TMBA, a natural inhibitor of cyclooxygenase-2, suppresses adipogenesis and promotes lipolysis in 3T3-L1 adipocytes. When treated with 100 μg/mL of 2,4,5-TMBA for 24, 48, or 72 h, the viability of fully differentiated 3T3-L1 adipocytes is decreased by 8.35, 15.54, and 27.26%, respectively. When the preadiocytes are treated with 100 μg/mL of 2,4,5-TMBA for 24 h before differentiation medium is supplemented, the cell viability is decreased by 26.46%^[3]. Asaronaldehyde exhibited significant anti-Candida activity (P = 0.0412). Minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC) were established as 0.25 and 0.5 mg/mL, respectively. It showed significant inhibition of hyphal form transition in yeast at MIC/2 and MIC/4 values^[4].
参考文献

[1] Chen CC, Chyau CC, Hseu TH. Production of a COX-2 inhibitor, 2,4,5-trimethoxybenzaldehyde, with submerged cultured Antrodia camphorata. Lett Appl Microbiol. 2007 Apr;44(4):387-92.
[2] Momin RA, De Witt DL, Nair MG. Inhibition of cyclooxygenase (COX) enzymes by compounds from Daucus carota L. Seeds. Phytother Res. 2003 Sep;17(8):976-9.
[3] Wu MR, Hou MH, Lin YL, Kuo CF. 2,4,5-TMBA, a natural inhibitor of cyclooxygenase-2, suppresses adipogenesis and promotes lipolysis in 3T3-L1 adipocytes. J Agric Food Chem. 2012;60(29):7262-7269
[4] Rajput SB, Shinde RB, Routh MM, Karuppayil SM. Anti-Candida properties of asaronaldehyde of Acorus gramineus rhizome and three structural isomers. Chin Med. 2013;8(1):18. Published 2013 Sep 8

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 5.0968 mL
- 25.4842 mL
- 50.9684 mL
- 5 mM
- 1.0194 mL
- 5.0968 mL
- 10.1937 mL
- 10 mM
- 0.5097 mL
- 2.5484 mL
- 5.0968 mL

技术信息

CAS号

4460-86-0

储存条件

粉末: Keep in dark place,Sealed in dry,Room Temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C10H12O4

运输

蓝冰

分子量

196.20

别名

细辛醛;Asaronaldehyde;2,4,5-trimethoxy-Benzaldehyde

溶解度

DMSO	135.0 mg/mL (688.1 mM)
Water	insoluble

动物实验配方

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