|2,2'-((环己烷-1,1-二基双(4,1-亚苯基))双(氧基))双(2-甲基丁酸)|CsnPharm

CAS No.: 30299-08-2

克利贝特 Catalog No. CSN10667

Synonyms: S-8527;Lipoclin;克利贝特

Clinofibrate is a HMG-CoA reductase inhibitor with IC50 value of 470 μM which can reduce plasma cholesterol levels and shows antihyperlipidemic effects.

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技术信息

生物活性

描述HMG-CoA (3-hydroxy-3-methylglutaryl-coenzyme A) reductase (HMGR) catalyzes the committed step in cholesterol biosynthesis^[3]. Clinofibrate is a hypelipidemic agent and a HMG-CoA reductase inhibitor with an IC₅₀ value of 0.47 mM^[4]. Clinofibrate administration (50 and 100 mg/kg/day, p.o.) significantly inhibits the increase in plasma fibrinogen level as well as serum- and VLDL-LDL-lipids^[5]. In rats which are refed either a fat-free diet or a 5% fat diet after a 2-day fast. clinofibrate at 30 mg/kg results in reductions of serum and liver triglyceride levels^[6]. Clinofibrate significantly decreases the high plasma cholesterol level of atherosclerotic rats, which is 823±256 mg/dl, or about ten times that of control rats (85±11 mg/dl). On treatment with clinofibrate, the cholesterol level is reduced most in the very low density lipoprotein (VLDL) fraction^[7]. Oral ingestion of Clinofibrate to normal rats for 7 days lowers serum triglycerides and cholesterol by about 27% at 1 mg/kg and 20% at 3 mg/kg, respectively^[8].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.1341 mL
- 10.6705 mL
- 21.3411 mL
- 5 mM
- 0.4268 mL
- 2.1341 mL
- 4.2682 mL
- 10 mM
- 0.2134 mL
- 1.0671 mL
- 2.1341 mL

技术信息

CAS号

30299-08-2

储存条件

粉末: Sealed in dry,Room Temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C28H36O6

运输

蓝冰

分子量

468.58

别名

S-8527;Lipoclin;克利贝特

溶解度

DMSO	100.0 mg/mL (213.4 mM)
Water	insoluble

动物实验配方

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