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CAS No.: 557-08-4

10-Undecenoic acid zinc salt/十一烯酸锌 Catalog No. CSN12240

Synonyms: Zinc undecylenate;Mycoseptin;Zinc(II)undec-10-enoate

10-Undecenoic Acid Zinc is used as starting reagent in the syntheses of pheromone (11Z)-hexadecenal and agriculturally important insect pheromones

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技术信息

生物活性

描述10-Undecenoic acid zinc is a natural or synthetic fungistatic fatty acid, and is used topically in creams against fungal infections, eczemas, ringworm, and other cutaneous conditions. The zinc provides an astringent action^[2]. 10-undecylenic acid (UA) is an OTC antifungal therapy and a nutritional supplement. 10-undecenoic acid zinc salt (UA), an anti-infective drug, could inhibit RdRp (ZIKV non-structural protein 5 RNA-dependent RNA polymerase) activity with a half maximal inhibitory concentration (IC50) of 1.13-1.25 µM. UA showed anti-ZIKV activity comparable to sofosbuvir^[3]. AbAf iCs (10-Undecenoic acid-injectable citrate-based mussel-inspired bioadhesives) not only showed strong wet tissue adhesion strength, but also exhibited excellent in vitro cyto-compatibility, fast degradation, and strong initial and considerable long-term anti-bacterial and anti-fungal ability^[4].
参考文献

[1] Chretien JH, Esswein JG, et al. Efficacy of undecylenic acid-zinc undecylenate powder in culture positive tinea pedis. Int J Dermatol. 1980 Jan-Feb;19(1):51-4.
[2] Brayden DJ, Walsh E. Efficacious intestinal permeation enhancement induced by the sodium salt of 10-undecylenic acid, a medium chain fatty acid derivative. AAPS J. 2014;16(5):1064‐1076
[3] Lin Y, Zhang H, Song W, Si S, Han Y, Jiang J. Identification and characterization of Zika virus NS5 RNA-dependent RNA polymerase inhibitors. Int J Antimicrob Agents. 2019;54(4):502‐506
[4] Guo J, Wang W, Hu J, et al. Synthesis and characterization of anti-bacterial and anti-fungal citrate-based mussel-inspired bioadhesives. Biomaterials. 2016;85:204‐217

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.3151 mL
- 11.5756 mL
- 23.1512 mL
- 5 mM
- 0.4630 mL
- 2.3151 mL
- 4.6302 mL
- 10 mM
- 0.2315 mL
- 1.1576 mL
- 2.3151 mL

技术信息

CAS号

557-08-4

储存条件

粉末: Inert atmosphere,Room Temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C22H38O4Zn

运输

蓝冰

分子量

431.94

别名

Zinc undecylenate;Mycoseptin;Zinc(II)undec-10-enoate;10-Undecenoic Acid Zinc Salt;十一烯酸锌

溶解度

DMSO	51.0 mg/mL (118.1 mM)
Water	insoluble

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10-Undecenoic acid zinc salt/十一烯酸锌 Catalog No. CSN12240

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