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CAS No.: 6953-61-3
Synonyms: HDAC8-IN-2;HDAC8-inhibitor-2;NSC-57457
1-Naphthohydroxamic acid (Compound 2) is a potent and selective HDAC8 inhibitor with an IC50 of 14 μM, and it is more selectively for HDAC8 than class I HDAC1 and class II HDAC6 (IC50 >100 μM). 1-Naphthohydroxamic acid does not increase global histone H4 acetylation and also does not reduce total intracellular HDAC activity, But it can induce tubulin acetylation.
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实验方案
技术信息
CAS号 | 6953-61-3 | 储存条件 |
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分子式 | C11H9NO2 | 运输 | 蓝冰 | |
分子量 | 187.19 | 别名 | HDAC8-IN-2;HDAC8-inhibitor-2;NSC-57457 |
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