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CAS No.: 149676-40-4

甲磺酸培氟沙星二水合物 Catalog No. CSN16100

Synonyms: Pefloxacin mesylate dihydrate

Pefloxacin mesylate, antibacterial agent, can prevent bacterial DNA replication via inhibiting DNA gyrase or topoisomerse.

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技术信息

生物活性

描述Pefloxacin is a synthetic fluoroquinolone antibiotic that is effectively against a wide range of Gram-negative and Gram-positive bacteria. Mesylate dihydrate salt is used for the tablet and injection formulations of pefloxacin. The minimal inhibitory concentrations (MICs) of pefloxacin for all genus and species of Enterobacteriaceae ranged between 0.03 and 4 or 8 mg/L, whereas the MICs of pefloxacin for Gram-negative bacteria were between 1 to 4mg/L. The antibacterial property of pefloxacin is resulted from its inhibition on DNA gyrase (topoisomerase II). Incubation of bacterial cells with pefloxacin induced non-replicative DNA synthesis in bacteria. Intravenous or oral administration of pefloxacin in doses up to 286 mg/kg did not cause any excitatory, anticholinergic, analgesic or antidepressant effects in rodents. Moreover, pefloxacin at 1-100 mg/L increased the phagocytic activity of polymorphonuclear phagocytes and alveolar macrophages against S. aureus by 35 to 40%, respectively, in rodents^[3].
动物研究
剂量
Rat: 40 mg/kg^[3] (p.o.)

给药途径
p.o.
参考文献

动物研究
剂量	Rat: 40 mg/kg^[3] (p.o.)
给药途径	p.o.

[1] Drlica K, Zhao X. DNA gyrase, topoisomerase IV, and the 4-quinolones. Microbiol Mol Biol Rev. 1997 Sep;61(3):377-92.
[2] Hussy P, Maass G, et al. Effect of 4-quinolones and novobiocin on calf thymus DNA polymerase alpha primase complex, topoisomerases I and II, and growth of mammalian lymphoblasts. Antimicrob Agents Chemother. 1986 Jun;29(6):1073-8.
[3] Bergogne-Bérézin E. Pefloxacin. Int J Antimicrob Agents. 1991;1(1):29-46. doi: 10.1016/0924-8579(91)90020-e. PMID: 18611491.

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.1483 mL
- 10.7413 mL
- 21.4826 mL
- 5 mM
- 0.4297 mL
- 2.1483 mL
- 4.2965 mL
- 10 mM
- 0.2148 mL
- 1.0741 mL
- 2.1483 mL

技术信息

CAS号

149676-40-4

储存条件

粉末: Keep in dark place,Inert atmosphere,Room temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C18H28FN3O8S

运输

蓝冰

分子量

465.49

别名

Pefloxacin mesylate dihydrate

溶解度

Water

50.0 mg/mL (107.4 mM)

动物实验配方

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甲磺酸培氟沙星二水合物 Catalog No. CSN16100

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