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CAS No.: 59227-89-3

月桂氮酮 Catalog No. CSN11274

Synonyms: N-Dodecylcaprolactam;Azone;N-0252

Laurocapram is a percutaneous enhancer, working by interacting with lipids in the stratum corneum. This may enhance the ability of the skin to absorb a hydrophilic chemical.

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技术信息

生物活性

描述Laurocapram, named as azone, is a new percutaneous penetration enhancer^[1]. In vitro studies, laurocapram could decrease skin permeation of celecoxib (CXB) and locate CXB in stratum corneum (SC), epidermis and dermis, while have not cytotoxicity or genotoxicity^[2]. Besides this, it was found that laurocapram could slowly release diazepam in buccal mucosa^[3]. In vivo studies, laurocapram has the ability of enhancing the transdermal absorption in mouse skin, through drilling the holes on the biomembrane and enlarging the orifice of hair follicles^[1]. In addition, laurocapram could contribute to the mild skin irritation and the inhibition of ear edema^[2].
参考文献

[1] Zhou JX, Dai ZQ, et al. [Influence of laurocapram on ultrastructures of mouse skin and sarcoma 180 membrane]. Zhongguo Yao Li Xue Bao. 1989;10(5):447-9.
[2] Senna TD, Mata Dos Santos HA, et al. In Vitro and In Vivo Evaluation of DMSO and Azone as Penetration Enhancers for Cutaneous Application of Celecoxib. Curr Drug Deliv. 2017;14(7):992-1004.
[3] Meng-Lund E, Jacobsen J, et al. Azone® decreases the buccal mucosal permeation of diazepam in a concentration-dependent manner via a reservoir effect. J Pharm Sci. 2014;103(4):1133-41.

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 3.5527 mL
- 17.7633 mL
- 35.5265 mL
- 5 mM
- 0.7105 mL
- 3.5527 mL
- 7.1053 mL
- 10 mM
- 0.3553 mL
- 1.7763 mL
- 3.5527 mL

技术信息

CAS号	59227-89-3	储存条件	粉末 Sealed in dry,Room Temperature 液体 -20°C:3-6 月 -80°C:12月
分子式	C18H35NO	运输	蓝冰
分子量	281.48	别名	N-Dodecylcaprolactam;Azone;N-0252;N-Lauryl caprolactam;Tranzone;月桂氮酮;月桂烯

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