生物活性

• 描述Trihexyphenidyl hydrochloride is an antiparkinsonian agent of the antimuscarinic class, binds to the M1 muscarinic receptor. Trihexyphenidyl (THP) is an anticholinergic drug misused to procure hallucination, sedation, and anxiolysis^[3]. Trihexyphenidyl Hydrochloride is a highly permeable drug and the transport mechanism is mainly via passive diffusion^[4]. The majority of patients (dystonia in children with cerebral palsy) tolerated trihexyphenidyl well on a schedule of gradual dose increases, and almost all demonstrated improvements in dystonia or sialorrhea or both^[5]. 2011;44(3):202‐206|. Trihexyphenidyl is consumed in association with alcohol, other licit drugs (benzodiazepines), or illicit drugs, impairing cognitive functions such as memory, attention, and learning, intervening with some activities of users' daily life^[6].
• 临床研究

• NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
  NCT01361373	Dystonic Cerebral Palsy	Phase 4	Unknown	August 2012	Israel ... more >> Shaare Zedek Medical Center Recruiting Jerusalem, Israel Contact: Hilla Ben- Pazi, MD       Benpazi@gmail.com Collapse <<
  NCT03430596	Extrapyramidal Syndrome	Early Phase 1	Not yet recruiting	June 2019	China, Shanghai ... more >> Shanghai Mental Health Center Shanghai, Shanghai, China, 200030 Collapse <<
  NCT00122044	Dystonia	Phase 2	Completed	-	United States, Alabama ... more >> University of Alabama School of Medicine Birmingham, Alabama, United States, 35233 United States, California Stanford University Stanford, California, United States, 94305-5235 United States, Illinois Rehabilitation Institute of Chicago Chicago, Illinois, United States, 60611 United States, Maryland Kennedy Krieger Institute Baltimore, Maryland, United States, 21205 United States, Missouri Washington University School of Medicine St. Louis, Missouri, United States, 63110 United States, New York University of Rochester Medical Center Rochester, New York, United States, 14642 United States, Texas Texas Scottish Rite Hospital for Children Dallas, Texas, United States, 75219 Collapse <<

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• 参考文献

• [1] Huang Y, Zhao Z, et al. Long-term trihexyphenidyl exposure alters neuroimmune response and inflammation in aging rat: relevance to age and Alzheimer's disease. J Neuroinflammation. 2016 Jul 1;13(1):175.

  [2] Amal M. Moustafa, et al. The Egyptian Journal of Histology. 2011, 34:687-696.

  [3] Torrents R, Ferré JF, Konareff A, et al. Misuse of Trihexyphenidyl (Artane) on Réunion Island. J Clin Psychopharmacol. 2018;38(3):250‐253

  [4] Lu C, Fu K, Cao K, et al. Permeability and transport mechanism of trihexyphenidyl hydrochloride in Caco-2 cell monolayer model with a validated UPLC-MS/MS method. J Pharm Biomed Anal. 2020;178:112924

  [5] Carranza-del Rio J, Clegg NJ, Moore A, Delgado MR. Use of trihexyphenidyl in children with cerebral palsy. Pediatr Neuro

  [6] Nappo SA, de Oliveira LG, Sanchez Zv, Carlini Ede A. Trihexyphenidyl (Artane): a Brazilian study of its abuse. Subst Use Misuse. 2005;40(4):473‐482

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