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CAS No.: 834-28-6

盐酸苯乙福明 Catalog No. CSN11690

Synonyms: Phenethylbiguanide hydrochloride;Phenethylbiguanide HCl;Phenformin (hydrochloride)

Phenformin HCl is an AMPK activator which can increase the phosphorylation and activation of AMPKalpha1 and AMPKalpha2.

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400-920-2911

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纯度 & 质量文件批次:

靶点选择性

生物活性

实验方案

技术信息

生物活性

描述AMP-activated protein kinase (AMPK) acts as a cellular energy sensor: it responds to an increase in AMP concentration ([AMP]) or the AMP-to-ATP ratio (AMP/ATP). Phenformin, which is from the biguanide class, have been reported to increase AMPK activity without increasing AMP/ATP. In hearts treated with phenformin for 18 min and then perfused for 20 min with Krebs-Henseleit buffer, [AMP] began to increase at 26 min and AMPK activity was elevated at 36 min, proving phenformin increased AMPK activity and phosphorylation in the isolated heart which was always preceded by and correlated with increased cytosolic [AMP] ^[1]. Phenformin suppressed amiloride-sensitive Na⁺ transport across H441 cells via a pathway that included activation of AMPK and inhibition of both apical Na⁺ entry through the epithelial sodium channel (ENaC) and basolateral Na⁺ extrusion via the Na⁺, K⁺-ATPase ^[2].
动物研究
剂量
Rat: 75 mg/kg^[2] (p.o.)
Mice: 300 mg/kg^[3] (p.o.)

给药途径
p.o.
参考文献

动物研究
剂量	Rat: 75 mg/kg^[2] (p.o.) Mice: 300 mg/kg^[3] (p.o.)
给药途径	p.o.

[1] Zhang L, He H, Balschi JA. Metformin and phenformin activate AMP-activated protein kinase in the heart by increasing cytosolic AMP concentration. Am J Physiol Heart Circ Physiol. 2007 Jul;293(1):H457-66. doi: 10.1152/ajpheart.00002.2007. Epub 2007 Mar 16. PMID: 17369473.
[2] Woollhead AM, Scott JW, Hardie DG, Baines DL. Phenformin and 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside (AICAR) activation of AMP-activated protein kinase inhibits transepithelial Na+ transport across H441 lung cells. J Physiol. 2005 Aug 1;566(Pt 3):781-92. doi: 10.1113/jphysiol.2005.088674. Epub 2005 May 26. PMID: 15919715; PMCID: PMC1464790.

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 4.1370 mL
- 20.6850 mL
- 41.3701 mL
- 5 mM
- 0.8274 mL
- 4.1370 mL
- 8.2740 mL
- 10 mM
- 0.4137 mL
- 2.0685 mL
- 4.1370 mL

技术信息

CAS号

834-28-6

储存条件

粉末: Keep in dark place,Inert atmosphere,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C10H16ClN5

运输

蓝冰

分子量

241.72

别名

Phenethylbiguanide hydrochloride;Phenethylbiguanide HCl;Phenformin (hydrochloride);Phenformin Hydrochloride;Phenformin HCl;Meltrol;Dipar;W-104144;ST50409947;D08352;盐酸苯乙福明;盐酸苯乙双胍

溶解度

DMSO	47.0 mg/mL (194.4 mM)
Water	47.0 mg/mL (194.4 mM)
Ethanol	10.0 mg/mL (41.4 mM)

动物实验配方

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