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CAS No.: 18956-16-6

豆蔻明 Catalog No. CSN25202

Synonyms: Cardamomin;Alpinetin chalcone;豆蔻明

Cardamonin (Cardamomin), a natural flavone isolated from Alpinia katsumadai Hayata, acts as an aryl hydrocarbon receptor (AhR) activator. Cardamonin alleviates inflammatory bowel disease by the inhibition of NLRP3 inflammasome activation via an AhR/Nrf2/NQO1 pathway .

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生物活性

描述Cardamonin, a chalcone extracted from cardamom spice with anti-inflammatory and anti-tumor activities. Cardamonin decreased viability of NPC(Nasopharyngeal carcinoma ) cells in a concentration-dependent manner. The IC50 values were 16.22 μM(CNE-1), 14.34 μM (CNE-2), 16.50 μM (HONE-1), and 68.12 μM (SUNE-1). Moreover, the expression level of the proapoptotic effector protein Bax and Bid was also markedly increased after treatment with cardamonin（15μM） in CNE-2 cells. In vivo, cardamonin (25 mg/kg once every other day from days 13) enhances chemotherapy efficacy.
参考文献

[1] Wang K, et al. Cardamonin, a natural flavone, alleviates inflammatory bowel disease by the inhibition of NLRP3 inflammasome activation via an AhR/Nrf2/NQO1 pathway. Biochem Pharmacol. 2018 Sep;155:494-509.

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 3.6999 mL
- 18.4993 mL
- 36.9987 mL
- 5 mM
- 0.7400 mL
- 3.6999 mL
- 7.3997 mL
- 10 mM
- 0.3700 mL
- 1.8499 mL
- 3.6999 mL

技术信息

CAS号	18956-16-6	储存条件	粉末 Sealed in dry,Room Temperature 液体 -20°C:3-6 月 -80°C:12月
分子式	C16H14O4	运输	蓝冰
分子量	270.28	别名	Cardamomin;Alpinetin chalcone;豆蔻明

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