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CAS No.: 951-78-0

2'-脱氧尿苷 Catalog No. CSN23622

Synonyms: NSC 23615;Uracil deoxyriboside;dU

2'-Deoxyuridine is frequently halogenated to create thymidine analogues which is useful in studies of DNA synthesis and degradation mechanisms.

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生物活性

描述2'-Deoxyuridine could increase chromosome breakage and results in a decreased thymidylate synthetase activity. A known use of 2'-Deoxyuridine is as a precursor in the synthesis of Edoxudine. The representative DNA-labeling agent 5-ethynyl-2'-deoxyuridine (EdU) was chemically modified to improve its function. Chemical monophosphorylation was expected to enhance the efficiency of the substrate in DNA polymerization by circumventing the enzymatic monophosphorylation step that consumes energy. The phosphorylated EdU (PEdU) was less toxic than EdU, and had the same or a slightly higher DNA-labeling ability in vitro. PEdU was also successfully applied to DNA labeling in vivo^[1]. Deoxyuridine (dU) increases chromosome breakage at folic acid (FA)-sensitive common fragile sites (mostly 3p14 and 16q23) in human lymphocytes. This dU-related increase can be suppressed by thymidine or FA^[2].
参考文献

[1] Seo S, Onizuka K, Nishioka C, Takahashi E, Tsuneda S, Abe H, Ito Y. Phosphorylated 5-ethynyl-2'-deoxyuridine for advanced DNA labeling. Org Biomol Chem. 2015 Apr 21;13(15):4589-95
[2] Reidy JA. Deoxyuridine increases folate-sensitive fragile site expression in human lymphocytes. Am J Med Genet. 1987 Jan;26(1):1-5

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 4.3821 mL
- 21.9106 mL
- 43.8212 mL
- 5 mM
- 0.8764 mL
- 4.3821 mL
- 8.7642 mL
- 10 mM
- 0.4382 mL
- 2.1911 mL
- 4.3821 mL

技术信息

CAS号

951-78-0

储存条件

粉末: Inert atmosphere,Room Temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C9H12N2O5

运输

蓝冰

分子量

228.20

别名

NSC 23615;Uracil deoxyriboside;dU;2'-脱氧尿苷;2-脱氧尿苷

溶解度

DMSO	45.0 mg/mL (197.2 mM)

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2'-脱氧尿苷 Catalog No. CSN23622

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