生物活性

• 靶点	HSV1 (feline) IC50:4.3μM

• 描述Idoxuridine is an iodinated analogue of deoxyuridine, with antiviral activity against herpes simplex virus (HSV) and potential radiosensitizing activities. Idoxuridine in dimethyl sulfoxide had no effect in recurrent or primary HSV on duration of symptoms, new lesion formation, healing time, or risk of subsequent recurrence. Complications in patients given idoxuridine in dimethyl sulfoxide included local burning, generalized contact dermatitis, and vulvar carcinoma in situ. Thirty percent idoxuridine in dimethyl sulfoxide has no effect on clinical manifestations of genital HSV infection and may be hazardous^[3]. herpesvirus type-1 Idoxuridine is mainly used topically to treat herpes simplex keratitis. Epithelial lesions, especially initial attacks presenting with a dendritic ulcer, are most responsive to therapy, while infection with stromal involvement are less responsive. Idoxuridine is ineffective against herpes simplex virus type 2 and varicella-zoster^[4]. In addition, Radiosensitizers such as idoxuridine incorporate into the DNA and increase the susceptibility of the cancer cell to radiation damage^[5].
• 临床研究

• NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
  NCT02381561	Advanced Bile Duct Carcinoma ... more >> Stage II Esophageal Cancer AJCC v7 Stage II Pancreatic Cancer AJCC v6 and v7 Stage IIA Esophageal Cancer AJCC v7 Stage IIA Pancreatic Cancer AJCC v6 and v7 Stage IIB Esophageal Cancer AJCC v7 Stage IIB Pancreatic Cancer AJCC v6 and v7 Stage III Colon Cancer AJCC v7 Stage III Esophageal Cancer AJCC v7 Stage III Gastric Cancer AJCC v7 Stage III Liver Cancer Stage III Pancreatic Cancer AJCC v6 and v7 Stage III Rectal Cancer AJCC v7 Stage III Small Intestinal Cancer AJCC v7 Stage IIIA Colon Cancer AJCC v7 Stage IIIA Esophageal Cancer AJCC v7 Stage IIIA Gastric Cancer AJCC v7 Stage IIIA Rectal Cancer AJCC v7 Stage IIIA Small Intestinal Cancer AJCC v7 Stage IIIB Colon Cancer AJCC v7 Stage IIIB Esophageal Cancer AJCC v7 Stage IIIB Gastric Cancer AJCC v7 Stage IIIB Rectal Cancer AJCC v7 Stage IIIB Small Intestinal Cancer AJCC v7 Stage IIIC Colon Cancer AJCC v7 Stage IIIC Esophageal Cancer AJCC v7 Stage IIIC Gastric Cancer AJCC v7 Stage IIIC Rectal Cancer AJCC v7 Stage IV Colon Cancer AJCC v7 Stage IV Esophageal Cancer AJCC v7 Stage IV Gastric Cancer AJCC v7 Stage IV Liver Cancer Stage IV Pancreatic Cancer AJCC v6 and v7 Stage IV Rectal Cancer AJCC v7 Stage IV Small Intestinal Cancer AJCC v7 Stage IVA Colon Cancer AJCC v7 Stage IVA Liver Cancer Stage IVA Rectal Cancer AJCC v7 Stage IVB Colon Cancer AJCC v7 Stage IVB Liver Cancer Stage IVB Rectal Cancer AJCC v7 Collapse <<	Phase 1	Recruiting	-	United States, Rhode Island ... more >> Rhode Island Hospital Recruiting Providence, Rhode Island, United States, 02903 Contact: Timothy J. Kinsella    401-444-8311    tkinsella@lifespan.org    Principal Investigator: Timothy J. Kinsella Collapse <<
  NCT00159978	-	-	Terminated(Problems with FMISO... more >> supply) Collapse <<	-	Netherlands ... more >> UMC St Radboud, Department of Radiotherapy Nijmegen, Gelderland, Netherlands, 6500 HB Collapse <<
  NCT00003405	Leukemia	Phase 2	Unknown	-	United States, Illinois ... more >> Cook County Hospital Chicago, Illinois, United States, 60612-9985 Rush Cancer Institute Chicago, Illinois, United States, 60612 Angelo P. Creticos, M.D. Cancer Center Chicago, Illinois, United States, 60657 Rush-Riverside Cancer Center Kankakee, Illinois, United States, 60901 Collapse <<

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• 参考文献

• [1] De Clercq E. Selective anti-herpesvirus agents. Antivir Chem Chemother. 2013 Jan 23;23(3):93-101.

  [2] Maggs DJ, Clarke HE. In vitro efficacy of ganciclovir, cidofovir, penciclovir, foscarnet, idoxuridine, and acyclovir against feline herpesvirus type-1. Am J Vet Res. 2004 Apr;65(4):399-403.

  [3] Silvestri DL, Corey L, Holmes KK. Ineffectiveness of topical idoxuridine in dimethyl sulfoxide for therapy for genital herpes. JAMA. 1982 Aug 27;248(8):953-9

  [4] Seth AK, Misra A, Umrigar D. Topical liposomal gel of idoxuridine for the treatment of herpes simplex: pharmaceutical and clinical implications. Pharm Dev Technol. 2004 Aug;9(3):277-89

  [5] Otto SE. Radiopharmaceuticals (Strontium 89) and radiosensitizers (idoxuridine). J Intraven Nurs. 1998 Nov-Dec;21(6):335-7

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