|1-((1S,2S)-1-羟基-1-(4-羟基苯基)丙-2-基)-4-苯基哌啶-4-醇甲磺酸三水合物|CsnPharm

欢迎来到CSNpharm！产品仅用于科研！

400-920-2911 sales@csnpharm.cn

^NEW 新产品

登录 | 注册会员中心 0

您的位置 : 首页 / Neuronal Signaling / NMDAR / 1-((1S,2S)-1-Hydroxy-1-(4-hydroxyphenyl)propan-2-yl)-4-phenylpiperidin-4-ol methanesulfonate trihydrate

CAS No.: 189894-57-3

1-((1S,2S)-1-Hydroxy-1-(4-hydroxyphenyl)propan-2-yl)-4-phenylpiperidin-4-ol methanesulfonate trihydrate Catalog No. CSN24287

Synonyms: CP-101,60 mesylate, CP-101606-27, Traxoprodil mesylate;CP-101,60 mesylate;CP-101606-27

Traxoprodil a selective antagonist of the NR2B subunit of the NMDA receptor.

规格	价格	促销价格	库存	数量

400-920-2911

sales@csnpharm.cn

tech@csnpharm.cn

加入购物车大规格询价

产品咨询

400-920-2911

sales@csnpharm.cn

tech@csnpharm.cn

纯度 & 质量文件批次:

靶点选择性

生物活性

描述Traxoprodil mesylate (CP101,606) is a potent and selective NMDA antagonist and protect hippocampal neurons with an IC50 of 10 nM. Traxoprodil is effective at 1 mg/kg to block NMDA (ip) stimulated cfos induction in mice^[1]. Traxoprodil (20nmol i.c.v.) increased the latency to generalized tonic-clonic seizures induced by PTZ (pentylenetetrazol) (70mg/kg; i.p.). Traxoprodil (60mg/kg, p.o.) increased the latency to clonic and generalized seizures, and decreased the total time spent in seizures^[2]. Traxoprodil at a dose of 20 and 40 mg/kg exhibited antidepressant activity in the FST (forced swim test) and it was not related to changes in animals' locomotor activity^[3].
参考文献

[1] Chenard BL, Bordner J, Butler TW, Chambers LK, Collins MA, De Costa DL, Ducat MF, Dumont ML, Fox CB, Mena EE, et al. (1S,2S)-1-(4-hydroxyphenyl)-2-(4-hydroxy-4-phenylpiperidino)-1-propanol: a potent new neuroprotectant which blocks N-methyl-D-aspartate responses. J Med Chem. 1995 Aug 4;38(16):3138-45
[2] Naspolini AP, Cocco AR, Villa Martignoni F, Oliveira MS, Furian AF, Rambo LM, Rubin MA, Barron S, Mello CF. Traxoprodil decreases pentylenetetrazol-induced seizures. Epilepsy Res. 2012 Jun;100(1-2):12-9
[3] Poleszak E, Stasiuk W, Szopa A, Wyska E, Serefko A, Oniszczuk A, Wośko S, Świąder K, Wlaź P. Traxoprodil, a selective antagonist of the NR2B subunit of the NMDA receptor, potentiates the antidepressant-like effects of certain antidepressant drugs in the forced swim test in mice. Metab Brain Dis. 2016 Aug;31(4):803-14

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.0939 mL
- 10.4697 mL
- 20.9394 mL
- 5 mM
- 0.4188 mL
- 2.0939 mL
- 4.1879 mL
- 10 mM
- 0.2094 mL
- 1.0470 mL
- 2.0939 mL

技术信息

CAS号	189894-57-3		储存条件	粉末 Inert atmosphere,2-8°C 液体 -20°C:3-6 月 -80°C:12月
分子式	C21H35NO9S		运输	蓝冰
分子量	477.57		别名	CP-101,60 mesylate, CP-101606-27, Traxoprodil mesylate;CP-101,60 mesylate;CP-101606-27

大规格询价

号为必填项

姓名: 邮箱: 手机号:

留言:

提交

总药量计算器 ✕

动物实验：给药剂量mg/kg 动物体重g 动物数量只每天给药次给药天

需要的总药量：mg

工作液计算器 ✕

动物实验：给药剂量mg/kg 动物体重g 给药体积μL

您需要配制的工作液浓度为：mg/mL

优势价格
快速发货
品质保证
技术支持

联系我们

sales@csnpharm.cn

官方电话：400-920-2911
二维码
微信公众号 CSN官网

dandb BBB norton fedex dhl ups 顺丰沪公网安备 31011002004927号，沪ICP备09052192号-6 危化品许可证:沪(杨)应急管危经许[2021]203479(QYS)

csnpharm版权所有2023，产品仅用于科研！