|1,8-二羟基蒽醌|CsnPharm

CAS No.: 117-10-2

1,8-二羟基蒽醌 Catalog No. CSN17102

Synonyms: Dantron;Chrysazin;1,8-Dihydroxyanthraquinone

1,8-Dihydroxyanthraquinone is a synthetic anthraquinone derivative, currently used as an antioxidant in synthetic lubricants, in the synthesis of antitumor agents, as a fungicide and as an intermediate for making dyes.

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技术信息

生物活性

描述1,8-Dihydroxyanthraquinone (Danthron) is a natural product extracted from the traditional Chinese medicine rhubarb. Danthron functions in regulating glucose and lipid metabolism by activating AMPK(AMP-activated protein kinase). Danthron (0.1, 1, and 10 μmol/L) dose-dependently promoted the phosphorylation of AMPK and acetyl-CoA carboxylase (ACC) in both HepG2 and C2C12 cells. Meanwhile, danthron treatment significantly reduced the lipid synthesis related sterol regulatory element-binding protein 1c (SREBP1c) and fatty acid synthetase (FAS) gene expressions, and the TC and TG levels. In addition, danthron treatment efficiently increased glucose consumption. The actions of danthron on lipid and glucose metabolism were abolished or reversed by co-treatment with the AMPK inhibitor compound C^[3]. Danthron inhibits 9-cis retinoic acid (9cRA)-induced retinoic X receptor α (RXRα) transactivation by IC50 at 0.11 μM. Danthron functions as an insulin sensitizer in vivo. Danthron improves insulin sensitivity in diet-induced obese (DIO) mice. The insulin tolerance test result shows that Danthron (5 mg/kg) treated diet-induced obesity mice exhibit lower glucose levels after insulin challenge, compared with the control vehicle-treated group^[4]. Danthron may prevent autophagy, inhibit proliferation and induce apoptosis in pancreatic cancer cells in vitro. Similarly, inhibition of autophagy by danthron also enhances toxicity of doxorubicin to pancreatic cancer cells^[5]. Danthron inhibited foam cell formation in oxidized low-density lipoprotein-induced RAW264.7 macrophages. Furthermore, danthron exerted its function in atherosclerosis at least partly through activating the AMP-activated protein kinase-sirtuin 1 signalling pathway^[6].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 4.1630 mL
- 20.8150 mL
- 41.6301 mL
- 5 mM
- 0.8326 mL
- 4.1630 mL
- 8.3260 mL
- 10 mM
- 0.4163 mL
- 2.0815 mL
- 4.1630 mL

技术信息

CAS号

117-10-2

储存条件

粉末: Keep in dark place,Sealed in dry,Room Temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C14H8O4

运输

蓝冰

分子量

240.21

别名

Dantron;Chrysazin;1,8-Dihydroxyanthraquinone;Antrapurol;Chrysazine;1,8-二羟基蒽醌;1，8-二羟基蒽醌

溶解度

DMSO	4.6 mg/mL (19.1 mM) warming
Water	insoluble

动物实验配方

IP	2% DMSO+2% Tween80+30% PEG300+water	0.2 mg/mL	clear
PO	0.5% CMC-Na	70 mg/mL	suspension

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