|1,8-二羟基-3-甲基蒽-9,10-二酮|CsnPharm

CAS No.: 481-74-3

大黄酚 Catalog No. CSN17313

Synonyms: 大黄酚;Chrysophanic acid

Chrysophanol, a natural anthraquinone isolated from Dianella longifolia, is an EGFR/mTOR pathway inhibitor.

规格	价格	促销价格	库存	数量

400-920-2911

sales@csnpharm.cn

tech@csnpharm.cn

加入购物车大规格询价

加入收藏

产品咨询

400-920-2911

sales@csnpharm.cn

tech@csnpharm.cn

纯度 & 质量文件批次:

靶点选择性

生物活性

实验方案

技术信息

生物活性

描述Chrysophanol, a herbaceous perennial plant, belonging to the Polygonaceae family, has anticancer, antiviral, anti-diabetic and anti-inflammatory biological properties. In vivo, the saturation value of drug binding for chrysophanol was 0.53. The obtained LD50 value for oral toxicity of chrsyphanol was 2.5 g/kg^[3]. In vitro, chrysophanol inhibited the proliferation of MCF-7 and MDA-MB-231 cells in a dose-dependent manner. In addition, chrysophanol facilitated paclitaxel induced apoptosis and downregulated Bcl-2^[4].
参考文献

[1] Lee MS, Cha EY, et al. Chrysophanic acid blocks proliferation of colon cancer cells by inhibiting EGFR/mTOR pathway. Phytother Res. 2011 Jun;25(6):833-7.
[2] Semple SJ, Pyke SM, et al. In vitro antiviral activity of the anthraquinone chrysophanic acid against poliovirus. Antiviral Res. 2001 Mar;49(3):169-78.
[3] Prateeksha, Yusuf MA, Singh BN, Sudheer S, Kharwar RN, Siddiqui S, Abdel-Azeem AM, Fernandes Fraceto L, Dashora K, Gupta VK. Chrysophanol: A Natural Anthraquinone with Multifaceted Biotherapeutic Potential. Biomolecules. 2019 Feb 18;9(2):68. doi: 10.3390/biom9020068. PMID: 30781696; PMCID: PMC6406798.
[4] Ren L, Li Z, Dai C, Zhao D, Wang Y, Ma C, Liu C. Chrysophanol inhibits proliferation and induces apoptosis through NF-κB/cyclin D1 and NF-κB/Bcl-2 signaling cascade in breast cancer cell lines. Mol Med Rep. 2018 Mar;17(3):4376-4382. doi: 10.3892/mmr.2018.8443. Epub 2018 Jan 17. PMID: 29344652; PMCID: PMC5802211.

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 3.9333 mL
- 19.6667 mL
- 39.3333 mL
- 5 mM
- 0.7867 mL
- 3.9333 mL
- 7.8667 mL
- 10 mM
- 0.3933 mL
- 1.9667 mL
- 3.9333 mL

技术信息

CAS号

481-74-3

储存条件

粉末: Inert atmosphere,Room Temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C15H10O4

运输

蓝冰

分子量

254.24

别名

大黄酚;Chrysophanic acid

溶解度

DMSO	5.0 mg/mL (19.7 mM) warming
Water	Insoluble
Ethanol	Insoluble

动物实验配方

大规格询价

号为必填项

姓名: 邮箱: 手机号:

留言:

提交

大黄酚 Catalog No. CSN17313

靶点选择性

请登录您的专属账户

确认信息