|1,2-二甲基-5-硝基咪唑|CsnPharm

CAS No.: 551-92-8

二甲硝咪唑 Catalog No. CSN13726

Synonyms: 1,2-Dimethyl-5-nitroimidazole;NSC 226253;RP 8595

Dimetridazole is a nitroimidazole class drug that combats protozoan infections.

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技术信息

生物活性

描述Dimetridazole is a nitroimidazole class drug that combats protozoan infections. Dimetridazole achieved higher MIC100 activity than metronidazole against the resistant isolate. The use of dimetridazole as a promising drug-like scaffold for novel therapeutic alternatives against T. vaginalis resistant infections^[3]. Dimetridazole was formulated for drinking water medication and as a prolonged-release tablet. To suppress a Trichomonas gallinae infection successfully, medicated drinking water containing dimetridazole (400 mg/L) had to be administered for at least 3 days. After intravenous administration of 20 mg dimetridazole, the drug plasma concentration-time profile fitted a one-compartment open model with a mean half-life of 3.9 h. The absolute bioavailability of the tablet in fasted pigeons was 83.8%. The bioavailability of the tablet administered with food was reduced by 20%^[4]. Dimetridazole, either when used alone or in conjunction with oxytetracycline, had a marked effect on ruminal function. Within 6 h of dosing, the ruminal pH fell to below 5, but then returned to pretreatment values over the next 24 - 48h^[5]. Dimetridazole at a concentration of 1.0 g/l in drinking water caused mortality in both ducklings and goslings. When given to goslings at a concentration of 0.5 g/l, the drug caused growth depression and nervous signs characterized by excess activity, abnormal head attitudes, and ataxia^[6].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 7.0858 mL
- 35.4288 mL
- 70.8577 mL
- 5 mM
- 1.4172 mL
- 7.0858 mL
- 14.1715 mL
- 10 mM
- 0.7086 mL
- 3.5429 mL
- 7.0858 mL

技术信息

CAS号

551-92-8

储存条件

粉末: Inert atmosphere,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C5H7N3O2

运输

蓝冰

分子量

141.13

别名

1,2-Dimethyl-5-nitroimidazole;NSC 226253;RP 8595;Emtryl;Emtrylvet;Emtrymix;二甲硝咪唑

溶解度

DMSO	28.0 mg/mL (198.4 mM)

动物实验配方

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