|三氯叔丁醇|CsnPharm

CAS No.: 57-15-8

三氯叔丁醇 Catalog No. CSN21964

Synonyms: Chlorbutol;Chloreton;Chloretone

Chlorobutanol is antibacterial and antifungal agent, used for preservative, sedative, hypnotic and weak local anesthetic.

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技术信息

生物活性

描述Chlorobutanol (CB) is a pharmaceutical preservative and the active ingredient in certain sedatives and anesthetics and produces adverse effects in adult tissues and mouse embryos in vitro. Dosing with 80 mg CB/kg produced maternal serum levels between 30.8 micrograms/mL (10 min) and < 1 microgram/mL (36 h), with a half-life of 7.45 h. Embryonic CB levels increased with maternal dose and were correlated with maternal serum levels^[1]. CB produces dysmorphogenesis in mouse embryos in vitro, and neurulating embryos are somewhat less sensitive than early limb-bud stage embryos. Preparations containing CB should be used with caution during pregnancy, particularly when repeated dosing may allow accumulation of CB to potentially embryotoxic levels^[2]. The combinations of chlorobutanol with methadone or terfenadine, another IKR blocker, produce synergistic IKR (the cardiac potassium current) block. The pharmacologic profile of chlorobutanol (synergistic IKR block) and its association with reports of TdP (torsades de pointes) and QT prolongation suggest the need for a full evaluation of its cardiac safety when used as a preservative in IV drug and vitamin formulations^[3].
参考文献

[1] Smoak IW, Amiss TJ. Chlorobutanol: maternal serum levels and placental transfer in the mouse. Vet Hum Toxicol. 1997;39(5):287‐290
[2] Smoak IW. Embryotoxic effects of chlorobutanol in cultured mouse embryos. Teratology. 1993;47(3):203‐208
[3] Woosley RD, Romero K, Heise CW, Gallo T, Tate J, Woosley RL. Summary of Torsades de Pointes (TdP) Reports Associated with Intravenous Drug Formulations Containing the Preservative Chlorobutanol. Drug Saf. 2019;42(7):907‐913

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 5.6352 mL
- 28.1759 mL
- 56.3517 mL
- 5 mM
- 1.1270 mL
- 5.6352 mL
- 11.2703 mL
- 10 mM
- 0.5635 mL
- 2.8176 mL
- 5.6352 mL

技术信息

CAS号

57-15-8

储存条件

粉末: Sealed in dry,Room Temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C4H7Cl3O

运输

蓝冰

分子量

177.46

别名

Chlorbutol;Chloreton;Chloretone;Chlortran|;Chlortran;Acetochlorone;Methaform;三氯叔丁醇

溶解度

DMSO	390.0 mg/mL (2197.7 mM)
Water	insoluble

动物实验配方

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