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CAS No.: 244240-24-2
LFM-A13 is a potent and selective inhibitor of Btk with IC50 of 17.2 μM and also inhibits PLK3 with IC50 of 7.2 μM.
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实验方案
技术信息
| CAS号 | 244240-24-2 | 储存条件 |
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| 分子式 | C11H8Br2N2O2 | 运输 | 蓝冰 | |
| 分子量 | 360.00 | 别名 |
| Cell Lines | Concentration | Assay Type | Time | Activity Description | Data Sources |
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| BT20 cells | 100 μM | Function assay | - | Induction of aberrant monopolar and multipolar spindle formation in human BT20 cells assessed as at 100 uM | 17098432 |
| PTK1 cells | 1 mM | Proliferation assay | 50 mins | Antiproliferative activity against prometaphase PTK1 cells assessed as complete arrest at 1 mM within 50 mins | 17098432 |
| Sf21 cells | - | Function assay | - | Inhibition of xenopus recombinant Plx1 expressed in Sf21 cells by measuring autophosphorylation by 15-mins kinase assay, IC50=10.3 μM | 17098432 |
| U373 cells | 100 μM | Function assay | - | Induction of aberrant monopolar and multipolar spindle formation in human U373 cells at 100 uM | 17098432 |
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