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CAS No.: 850140-72-6

阿法替尼 Catalog No. CSN12703

Synonyms: BIBW 2992;BIBW-2992 E-Isomer;Afatinib E-Isomer

Afatinib E-isomer is an irreversible inhibitor of dual EGFR and HER2 that shows obvious activitives of EGFR wt, EGFR L858R, EGFR L858R/T790M and HER2 with IC50 of 0.5 nM, 0.4 nM, 10 nM and 14 nM respectively.

规格	价格	促销价格	库存	数量

400-920-2911

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纯度 & 质量文件批次:

靶点选择性

生物活性

实验方案

技术信息

生物活性

靶点 EGFR (T790M, L858R)

IC50:10nM EGFR (L858R)

IC50:0.4nM EGFR

IC50:0.5nM
描述Afatinib E-isomer is an irreversible, dual EGFR/HER2 inhibitor, shows potent activity against wild-type and mutant forms of EGFR and HER2, with IC50 of 0.5 nM, 0.4 nM, 10 nM and 14 nM for EGFR wt, EGFR L858R, EGFR L858R/T790M and HER2, respectively.
参考文献

[1] Wong CH, Ma BB, et al. Preclinical evaluation of afatinib (BIBW2992) in esophageal squamous cell carcinoma (ESCC). Am J Cancer Res. 2015 Nov 15;5(12):3588-99.
[2] Li D, Ambrogio L, et al. BIBW2992, an irreversible EGFR/HER2 inhibitor highly effective in preclinical lung cancer models. Oncogene. 2008 Aug 7;27(34):4702-11.

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.0579 mL
- 10.2894 mL
- 20.5787 mL
- 5 mM
- 0.4116 mL
- 2.0579 mL
- 4.1157 mL
- 10 mM
- 0.2058 mL
- 1.0289 mL
- 2.0579 mL

技术信息

CAS号

850140-72-6

储存条件

粉末: Keep in dark place,Sealed in dry,Store in freezer, under -20°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C24H25ClFN5O3

运输

蓝冰

分子量

485.94

别名

BIBW 2992;BIBW-2992 E-Isomer;Afatinib E-Isomer;trade name: Gilotrif;Tomtovok and Tovok;阿法替尼;阿法替尼 E-异构体

溶解度

DMSO	96.0 mg/mL (197.6 mM)
Water	Insoluble
Ethanol	14.0 mg/mL (28.8 mM)

动物实验配方

2% DMSO+30% PEG 300+5% Tween 80+water

10 mg/mL

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靶点	Description	IC50
EGFR (T790M, L858R)		IC50:10nM
EGFR (L858R)		IC50:0.4nM
EGFR		IC50:0.5nM

阿法替尼 Catalog No. CSN12703

靶点选择性

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