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CAS No.: 5508-58-7

穿心莲内酯 Catalog No. CSN19420

Synonyms: 穿心莲内酯;Andrographis

Andrographolide is a naturally occuring NF-κB inhibitor.

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技术信息

生物活性

描述Andrographolide (AP) is a NF-κB inhibitor, which inhibits NF-κB activation through covalent modification of a cysteine residue on p50 in endothelial cells without affecting IκBα degradation or p50/p65 nuclear translocation. Treatment with Andrographolide (5 or 30mg/kg) reduces the extent of bone loss induced by LPS. Moreover, Andrographolide slightly increases the BMD and cortex thickness compared to LPS treatment^[3]. Andrographolide ameliorates RILI by suppressing AIM2 inflammasome mediated-pyroptosis in macrophage, identifying Andrographolide as a novel potential protective agent for RILI(Radiation-induced lung injury)^[4]. Andrographolide administration improved behavioural deficits and attenuated loss of dopaminergic neurons in MPTP-exposed mice and reduced cell death induced by rotenone in vitro. Andrographolide bound to DRP1 and inhibited its GTPase activity, thereby preventing excessive mitochondria fission and neuronal damage in PD^[5]. Andr (Andrographolide) markedly attenuated cardiac fibrosis and relieved inflammation after myocardial infarction. Andr significantly blocked oxidative stress and the nuclear translocation of p-P65 following myocardial infarction^[6].
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT02003651	Acute Respiratory Infections	Not Applicable	Completed	-	United States, North Carolina ... more >> ASU-NCRC Human Performance Lab Kannapolis, North Carolina, United States, 28081 Collapse <<
NCT02539277	Acute Upper Respiratory Infect... more >>ion Collapse <<	Phase 4	Unknown	November 2015	China, Beijing ... more >> Guang'anmen Hospital Recruiting Beijing, Beijing, China, 100053 Contact: Wensheng Qi Collapse <<
NCT00749645	Arthritis, Rheumatoid	Phase 2	Completed	-	Chile ... more >> HOSPITAL REGIONAL de OSORNO Osorno, Los Lagos, Chile, 5290000 Hospital Clínico Regional Valdivia, Los Ríos, Chile, 5090000 Collapse <<

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参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.8535 mL
- 14.2674 mL
- 28.5348 mL
- 5 mM
- 0.5707 mL
- 2.8535 mL
- 5.7070 mL
- 10 mM
- 0.2853 mL
- 1.4267 mL
- 2.8535 mL

技术信息

CAS号

5508-58-7

储存条件

粉末: Keep in dark place,Sealed in dry,Room Temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C20H30O5

运输

蓝冰

分子量

350.45

别名

穿心莲内酯;Andrographis

溶解度

DMSO	68.0 mg/mL (194.0 mM)
Water	Insoluble
Ethanol	Insoluble

动物实验配方

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NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点

NCT02003651	Acute Respiratory Infections	Not Applicable	Completed	-	United States, North Carolina ... more >> ASU-NCRC Human Performance Lab Kannapolis, North Carolina, United States, 28081 Collapse <<
NCT02539277	Acute Upper Respiratory Infect... more >>ion Collapse <<	Phase 4	Unknown	November 2015	China, Beijing ... more >> Guang'anmen Hospital Recruiting Beijing, Beijing, China, 100053 Contact: Wensheng Qi Collapse <<
NCT00749645	Arthritis, Rheumatoid	Phase 2	Completed	-	Chile ... more >> HOSPITAL REGIONAL de OSORNO Osorno, Los Lagos, Chile, 5290000 Hospital Clínico Regional Valdivia, Los Ríos, Chile, 5090000 Collapse <<
NCT03455049	Increased Insulin	Not Applicable	Recruiting	May 30, 2018	Indonesia ... more >> Faculty of Medicine, Universitas Indonesia Recruiting Jakarta Pusat, DKI Jakarta, Indonesia, 10430 Contact: Tri Juli Edi Tarigan, MD +62 813 15 483 293 tje_tar@yahoo.com Contact: Nida Amalina, PH +62 856 9703 6895 amalinanida@gmail.com Collapse <<
NCT02280876	Multiple Sclerosis, Relapsing-... more >>Remitting Collapse <<	Phase 1 Phase 2	Completed	-	Chile ... more >> Hospital Regional Valdivia, Los Ríos, Chile, 5090000 Collapse <<
NCT03132610	Acute Exacerbation of Chronic ... more >>Bronchitis Collapse <<	Phase 4	Recruiting	June 1, 2018	China, Jiangxi ... more >> The First Affiliated Hospital of Nanchang University Recruiting Nanchang, Jiangxi, China, 330029 Contact: Wei Zhang +86 0790-88694316 Collapse <<
NCT03132623	Acute Bronchitis	Phase 4	Recruiting	June 1, 2018	China, Jiangxi ... more >> The First Affiliated Hospital of Nanchang University Recruiting Nanchang, Jiangxi, China, 330029 Contact: Wei Zhang +86 0790-88694316 Collapse <<
NCT01993472	Colorectal Neoplasms	Phase 2	Unknown	June 2016	China, Jiangsu ... more >> the First Affiliated Hospital of Nanjing Medical University Not yet recruiting Nanjing, Jiangsu, China, 210029 Contact: Yanhong Gu, Ph.D 13813908678 oncotar@163.com Principal Investigator: Yanhong Gu, Ph.D Principal Investigator: Yongqian Shu, Ph.D Collapse <<
NCT03190044	Migraine Disorders	Not Applicable	Recruiting	December 31, 2019	Italy ... more >> Policlinico Umberto I Recruiting Rome, Italy, 00161 Contact: Cherubino Di Lorenzo, MD, PhD +393286783246 cherubino.dilorenzo@uniroma1.it Contact: Francesco Pierelli, MD francesco.pierelli@uniroma1.it Collapse <<
NCT03134443	Acute Tonsillitis	Phase 4	Recruiting	June 1, 2018	China, Jiangxi ... more >> The First Affiliated Hospital of Nanchang University Recruiting Nanchang, Jiangxi, China, 330029 Contact: Wei Zhang +86 0790-88694316 Collapse <<
NCT02273635	Primary Progressive Multiple S... more >>clerosis Multiple Sclerosis, Secondary Progressive Collapse <<	Phase 1 Phase 2	Unknown	April 2017	Chile ... more >> Multiple Sclerosis Centre, Pontificia Universidad Catolica de Chile Recruiting Santiago, Metropolitana, Chile, 8330033 Contact: Claudia A Carcamo, MD, PhD. 56 2 3546885 ccarcamo@med.puc.cl Contact: Ana C Reyes, Nurse 56 2 3546885 acreyes@med.puc.cl Collapse <<

穿心莲内酯 Catalog No. CSN19420

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