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CAS No.: 578-86-9

甘草素 Catalog No. CSN12274

Synonyms: 4',7-Dihydroxyflavanone;MF-101;Menerba

Liquiritigenin is an estrogenic compound which fuctions as a selective agonist of the estrogen receptor ERβ and an partial agonist of ERα. It also has choleretic effect. Liquiritigenin is a flavanone extracted from glycyrrhiza uralensis with antitumour action.

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靶点选择性

生物活性

实验方案

技术信息

生物活性

描述Liquiritigenin, a flavanone isolated from Glycyrrhiza uralensis, is a highly selective estrogen receptor β (ERbeta) agonist with an EC50 of 36.5 nM for activation of the ERE tk-Luc. The ERbeta-selectivity of liquiritigenin was due to the selective recruitment of the coactivator steroid receptor coactivator-2 to target genes^[3]. Pretreatment of MC3T3-E1 cells with liquiritigenin prevented the MG-induced cell death and production of protein adduct, intracellular reactive oxygen species, mitochondrial superoxide, cardiolipin peroxidation, and TNF-α in osteoblastic MC3T3-E1 cells. In addition, liquiritigenin increased the activity of glyoxalase I inhibited by MG(Methylglyoxal). The nitric oxide and PGC-1α levels were significantly increased by liquiritigenin, suggesting that liquiritigenin may induce mitochondrial biogenesis^[4]. Treatment with liquiritigenin significantly reduced the concentrations of pro-inflammatory cytokines including interleukin (IL)-6, IL-1β and tumor necrosis factor (TNF)-α in serum and hippocampus. The administrations of liquiritigenin, increased levels of superoxide dismutase (SOD), glutathione (GSH), catalase (CAT), and decreased Malondialdehyde (MDA) content. Mice treated with liquiritigenin showed restored levels of neurotransmitter norepinephrine (NE) and serotonin (5-HT)^[5].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 3.9024 mL
- 19.5119 mL
- 39.0239 mL
- 5 mM
- 0.7805 mL
- 3.9024 mL
- 7.8048 mL
- 10 mM
- 0.3902 mL
- 1.9512 mL
- 3.9024 mL

技术信息

CAS号

578-86-9

储存条件

粉末: Inert atmosphere,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C15H12O4

运输

蓝冰

分子量

256.25

别名

4',7-Dihydroxyflavanone;MF-101;Menerba;甘草素

溶解度

DMSO	51.0 mg/mL (199.0 mM)

动物实验配方

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甘草素 Catalog No. CSN12274

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