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CAS No.: 480-41-1

柚皮素 Catalog No. CSN18704

Synonyms: 柚皮素

Naringenin could suppess ERK2 activity and decrease stability of FRA1. It is a predominant flavanone derived from plant food with antioxidant effect.

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靶点选择性

生物活性

实验方案

技术信息

生物活性

描述Naringenin, a citrus flavonoid that possesses various biological activities, possesses a broad range of biological and pharmacological activities. Naringenin (50 mg/kg) inhibits both inflammatory pain and neurogenic inflammation^[3].Treating the WT mice with NGN (100 mg/kg/d) significantly attenuated hepatic lipid accumulation and inflammation activation in the mice livers induced by MCD diet^[4]. Naringenin protected against Cl4 induced rat liver fibrosis via Nrf2/ARE and NF-κB signaling pathway^[5].
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT02380144	Healthy	Not Applicable	Unknown	July 2017	Germany ... more >> Chair of Plant Foodstuff Technology and Analysis (150d), University of Hohenheim Stuttgart, Baden-Württemberg, Germany, 70599 Collapse <<
NCT03527277	Cardiovascular Risk Factor ... more >> Type2 Diabetes Mellitus Insulin Sensitivity Metabolic Syndrome Collapse <<	Not Applicable	Recruiting	March 31, 2023	United States, California ... more >> University of California, Davis Recruiting Davis, California, United States, 95616 Contact: Kimber Stanhope, Ph.D. 530-752-3720 klstanhope@ucdavis.edu Contact: Vivien Lee, B.S. 530-752-2714 vilee@ucdavis.edu Collapse <<
NCT01982734	Pharmacokinetics of New Curcum... more >>in Formulations Safety of New Curcumin Formulations Collapse <<	Early Phase 1	Completed	-	Germany ... more >> University of Hohenheim Stuttgart, Baden-Württemberg, Germany, 70599 Collapse <<

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参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 3.6731 mL
- 18.3653 mL
- 36.7306 mL
- 5 mM
- 0.7346 mL
- 3.6731 mL
- 7.3461 mL
- 10 mM
- 0.3673 mL
- 1.8365 mL
- 3.6731 mL

技术信息

CAS号

480-41-1

储存条件

粉末: Inert atmosphere,Room Temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C15H12O5

运输

蓝冰

分子量

272.25

别名

柚皮素

溶解度

DMSO	53.0 mg/mL (194.7 mM)
Water	Insoluble
Ethanol	5.0 mg/mL (18.4 mM)

动物实验配方

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NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点

NCT02380144	Healthy	Not Applicable	Unknown	July 2017	Germany ... more >> Chair of Plant Foodstuff Technology and Analysis (150d), University of Hohenheim Stuttgart, Baden-Württemberg, Germany, 70599 Collapse <<
NCT03527277	Cardiovascular Risk Factor ... more >> Type2 Diabetes Mellitus Insulin Sensitivity Metabolic Syndrome Collapse <<	Not Applicable	Recruiting	March 31, 2023	United States, California ... more >> University of California, Davis Recruiting Davis, California, United States, 95616 Contact: Kimber Stanhope, Ph.D. 530-752-3720 klstanhope@ucdavis.edu Contact: Vivien Lee, B.S. 530-752-2714 vilee@ucdavis.edu Collapse <<
NCT01982734	Pharmacokinetics of New Curcum... more >>in Formulations Safety of New Curcumin Formulations Collapse <<	Early Phase 1	Completed	-	Germany ... more >> University of Hohenheim Stuttgart, Baden-Württemberg, Germany, 70599 Collapse <<
NCT03032861	Intestinal Diseases	Not Applicable	Completed	-	Brazil ... more >> Sao Paulo State University "Julio de Mesquita Filho", Faculdade de Ciências Farmacêuticas Araraquara, Sao Paulo, Brazil, 14800-903 Collapse <<
NCT00539916	Cardiovascular Disease Risk Fa... more >>ctors Collapse <<	Not Applicable	Completed	-	France ... more >> Hopital Saint André - Service de Médecine Interne - Pathologie Vasculaire Bordeaux, France, 33075 Collapse <<
NCT03582553	Safety Issues ... more >> Pharmacokinetics Collapse <<	Early Phase 1	Completed	-	United States, Louisiana ... more >> Pennington Biomedical Research Center Baton Rouge, Louisiana, United States, 70808 Collapse <<
NCT02627547	Healthy	Not Applicable	Completed	-	United Kingdom ... more >> University of Glasgow School of Medicine Glasgow, United Kingdom Collapse <<
NCT01091077	Hepatitis C Virus ... more >> HCV Infection Chronic HCV Hepatitis C Collapse <<	Phase 1	Completed	-	United States, Massachusetts ... more >> Massachusetts General Hospital Boston, Massachusetts, United States, 02114 Collapse <<

柚皮素 Catalog No. CSN18704

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